Effectiveness of Secukinumab in the treatment of moderate-severe hidradenitis suppurativa: results from an Italian multicentric retrospective study in a real-life setting

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle. Albeit its pathogenesis is multifactorial, HS is regarded as mainly autoinflammatory in its origin. In particular, the high expression levels of interleukin (IL)-17A in the bloodstream and in lesional skin, of patients with HS, allows us to consider secukinumab as a potential drug capable of arresting the inflammatory cascade that characterizes this complicated pathology.