Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle. Albeit its pathogenesis is multifactorial, HS is regarded as mainly autoinflammatory in its origin. In particular, the high expression levels of interleukin (IL)-17A in the bloodstream and in lesional skin, of patients with HS, allows us to consider secukinumab as a potential drug capable of arresting the inflammatory cascade that characterizes this complicated pathology.

Effectiveness of Secukinumab in the treatment of moderate-severe hidradenitis suppurativa: results from an Italian multicentric retrospective study in a real-life setting / S. Ribero, A. Ramondetta, G. Fabbrocini, V. Bettoli, C. Potenza, A. Chiricozzi, M. Licciardello, A.V. Marzano, L. Bianchi, G. Rozzo, L. Fania, C. Marasca, G. Odorici, A. Mambrin, C. Moltrasio, R.D. Caposiena Caro, N. Skroza, P. Quaglino, N. Siliquini, P. Dapavo. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - (2021). [Epub ahead of print] [10.1111/jdv.17178]

Effectiveness of Secukinumab in the treatment of moderate-severe hidradenitis suppurativa: results from an Italian multicentric retrospective study in a real-life setting

A.V. Marzano;
2021

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle. Albeit its pathogenesis is multifactorial, HS is regarded as mainly autoinflammatory in its origin. In particular, the high expression levels of interleukin (IL)-17A in the bloodstream and in lesional skin, of patients with HS, allows us to consider secukinumab as a potential drug capable of arresting the inflammatory cascade that characterizes this complicated pathology.
HiSCR; IHS4; adalimumab; hidradenitis suppurativa; secukinumab
Settore MED/35 - Malattie Cutanee e Veneree
mar-2021
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/821645
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