Ganglionic eminence is the main transitory proliferative structure of the ventral telencephalon in human fetal brain and it contributes for at least 35% to the population of cortical interneurons; however data on the human GE anomalies are scarce. We report 5 fetal MR imaging observations with bilateral symmetric cavitations in their GE regions resembling an inverted open C shape and separating the GE itself form the deeper parenchyma. Imaging, neuropathology, and follow-up features suggested a malformative origin. All cases had in common characteristics of lissencephaly with agenesis or severe hypoplasia of corpus callosum of probable different genetic basis. From our preliminary observation, it seems that GE cavitations are part of conditions which are also accompanied by severe cerebral structure derangement.

Bilateral cavitations of ganglionic eminence: A fetal MR imaging sign of halted brain development / A. Righini, C. Frassoni, F. Inverardi, C. Parazzini, D. Mei, C. Doneda, T.J. Re, I. Zucca, R. Guerrini, R. Spreafico, F. Triulzi. - In: AJNR, AMERICAN JOURNAL OF NEURORADIOLOGY. - ISSN 0195-6108. - 34:9(2013 Sep), pp. 1841-1845. [10.3174/ajnr.A3508]

Bilateral cavitations of ganglionic eminence: A fetal MR imaging sign of halted brain development

Righini A.;Doneda C.;Re T. J.;Triulzi F.
2013-09

Abstract

Ganglionic eminence is the main transitory proliferative structure of the ventral telencephalon in human fetal brain and it contributes for at least 35% to the population of cortical interneurons; however data on the human GE anomalies are scarce. We report 5 fetal MR imaging observations with bilateral symmetric cavitations in their GE regions resembling an inverted open C shape and separating the GE itself form the deeper parenchyma. Imaging, neuropathology, and follow-up features suggested a malformative origin. All cases had in common characteristics of lissencephaly with agenesis or severe hypoplasia of corpus callosum of probable different genetic basis. From our preliminary observation, it seems that GE cavitations are part of conditions which are also accompanied by severe cerebral structure derangement.
Agenesis of Corpus Callosum; Female; Humans; Magnetic Resonance Imaging; Male; Prenatal Diagnosis; Reproducibility of Results; Sensitivity and Specificity; Telencephalon
Settore MED/37 - Neuroradiologia
AJNR, AMERICAN JOURNAL OF NEURORADIOLOGY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/821568
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