Protein kinase C (PKCs) isoforms play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion, etc. Patterns of expression for each PKC isoform differ among tissues, and it is also clear that different PKCs are often not functionally redundant, for example specific PKCs mediate specific cellular signals required for activation, proliferation, differentiation and survival of immune cells. In the last 20 years, we have been studying the role of PKCs, mainly PKCβ and its anchoring protein RACK1 (Receptor for Activated C Kinase 1), in immune cell activation, and their implication in immunosenescence and immunotoxicity. We could demonstrate that PKCβ and RACK1 are central in dendritic cell maturation and activation by chemical allergens, and their expressions can be targeted by EDCs and anti-inflammatory drugs. In this chapter, current knowledge on the role of PKC in immune cell activation and possible implication in immunotoxicity will be described.

Role of Protein Kinase C in Immune Cell Activation and Its Implication Chemical-Induced Immunotoxicity / E. Corsini, E. Buoso, V. Galbiati, M. Racchi (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY). - In: Protein Kinase-mediated Decisions Between Life and Death / [a cura di] A.B. Engin, A. Engin. - Prima edizione. - [s.l] : Springer, 2021. - ISBN 9783030498436. - pp. 151-163 [10.1007/978-3-030-49844-3_6]

Role of Protein Kinase C in Immune Cell Activation and Its Implication Chemical-Induced Immunotoxicity

E. Corsini
Primo
Membro del Collaboration Group
;
V. Galbiati
Penultimo
Membro del Collaboration Group
;
2021

Abstract

Protein kinase C (PKCs) isoforms play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion, etc. Patterns of expression for each PKC isoform differ among tissues, and it is also clear that different PKCs are often not functionally redundant, for example specific PKCs mediate specific cellular signals required for activation, proliferation, differentiation and survival of immune cells. In the last 20 years, we have been studying the role of PKCs, mainly PKCβ and its anchoring protein RACK1 (Receptor for Activated C Kinase 1), in immune cell activation, and their implication in immunosenescence and immunotoxicity. We could demonstrate that PKCβ and RACK1 are central in dendritic cell maturation and activation by chemical allergens, and their expressions can be targeted by EDCs and anti-inflammatory drugs. In this chapter, current knowledge on the role of PKC in immune cell activation and possible implication in immunotoxicity will be described.
Protein kinase C; Immunity; Hormones; Xenobiotics; Receptor for activated C kinase; Immunotoxicity
Settore BIO/14 - Farmacologia
Book Part (author)
File in questo prodotto:
File Dimensione Formato  
6_Online PDF proof.pdf

accesso riservato

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 1.3 MB
Formato Adobe PDF
1.3 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Corsini2021_Chapter_RoleOfProteinKinaseCInImmuneCe.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 596.02 kB
Formato Adobe PDF
596.02 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/821021
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact