Objective: The main objective of this study was to estimate the efficacy of influenza vaccination in reducing influenza-attributable hospitalization and emergency room (ER) admission for severe complications and influenza-attributable excess mortality in individuals ≥65 years of age. Methods: We analyzed the ≥65 years-old community (n = 952,822) afferent to the Brescia (Northern Italy) Health Protection Agency, considered an Italian population reference, to evaluate the efficacy of influenza vaccination (seasons 2014–17) in reducing deaths, ER-admissions, and hospitalizations for influenza-related complications in the elderly. Results: A protective effect of influenza vaccination emerged in reducing hospitalization and ER admission for diseases of the respiratory system and for death from all causes in people ≥65 years. The major effect of influenza vaccination was the reduction in risk of death from all causes, increasing with age and comorbidity. Conclusion: Influenza vaccination has reduced the number of ER admissions and hospitalizations caused by influenza-related complications and has prevented death among high-risk groups in elderly ≥65 years, resulting in social and public health cost savings. Stronger or new vaccination strategies are needed to improve vaccination rates among the elderly.

Evaluation of influenza vaccination efficacy in reducing influenza-related complications and excess mortality in Northern Italy (2014-2017) / G. Marano, P. Boracchi, E. Luconi, E. Pariani, L. Pellegrinelli, C. Galli, C.E. Gandolfi, M. Magoni, A. Piro, C. Scarcella, S. Castaldi, E.M. Biganzoli. - In: EXPERT REVIEW OF VACCINES. - ISSN 1476-0584. - 20:1(2021 Jan), pp. 73-81. [10.1080/14760584.2021.1874927]

Evaluation of influenza vaccination efficacy in reducing influenza-related complications and excess mortality in Northern Italy (2014-2017)

G. Marano
Primo
;
P. Boracchi
Secondo
;
E. Luconi;E. Pariani;L. Pellegrinelli;C. Galli;C.E. Gandolfi;S. Castaldi
Penultimo
;
E.M. Biganzoli
Ultimo
2021

Abstract

Objective: The main objective of this study was to estimate the efficacy of influenza vaccination in reducing influenza-attributable hospitalization and emergency room (ER) admission for severe complications and influenza-attributable excess mortality in individuals ≥65 years of age. Methods: We analyzed the ≥65 years-old community (n = 952,822) afferent to the Brescia (Northern Italy) Health Protection Agency, considered an Italian population reference, to evaluate the efficacy of influenza vaccination (seasons 2014–17) in reducing deaths, ER-admissions, and hospitalizations for influenza-related complications in the elderly. Results: A protective effect of influenza vaccination emerged in reducing hospitalization and ER admission for diseases of the respiratory system and for death from all causes in people ≥65 years. The major effect of influenza vaccination was the reduction in risk of death from all causes, increasing with age and comorbidity. Conclusion: Influenza vaccination has reduced the number of ER admissions and hospitalizations caused by influenza-related complications and has prevented death among high-risk groups in elderly ≥65 years, resulting in social and public health cost savings. Stronger or new vaccination strategies are needed to improve vaccination rates among the elderly.
cardiac disease and stroke; death from all causes; diseases of the respiratory system; Efficacy of influenza vaccination; elderly
Settore MED/42 - Igiene Generale e Applicata
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/820716
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