This large pooled analysis of two studies shows no association of coffee and decaffeinated coffee with colorectal cancer risk. Background: Coffee contains many bioactive substances that can play a role on colorectal cancer. Epidemiological evidence of coffee intake and colorectal cancer is, however, inconsistent. Aim: To provide further information on the risk of colorectal cancer in relation to coffee consumption. Methods: Data derive from two companion case-control studies conducted in Italy and Spain within the European Union Project on Health Impacts of long-term exposure to disinfection by-products in Drinking Water and the Spanish Multi-Case Control study on Cancer. These included a total of 2289 incident cases with colorectal cancer and 3995 controls with information on coffee intake. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were derived from unconditional logistic regression models, adjusted for study centre, sex, age, education, smoking, and other covariates. Results: Compared with never coffee drinkers, the OR was 0.99 (95% CI 0.95-1.02) for total coffee consumption. There was no significant trend in risk with dose or duration, the ORs being 0.95 (95% CI 0.72-1.25) for an amount of five or more cups per day of coffee and 0.95 (95% CI 0.75-1.19) for a duration of consumption of 50 years or longer. The OR was 1.04 (95% CI 0.87-1.25) for two or more cups per day of decaffeinated coffee. There were no heterogeneity across strata of various covariates, as well as no apparent differences between various anatomical subsites. Conclusion: This large pooled analysis of two studies shows no association of coffee and decaffeinated coffee with colorectal cancer risk.
Coffee consumption and colorectal cancer risk / V. Rosato, V. Guercio, C. Bosetti, E. Gracia-Lavedan, M.C. Villanueva, J. Polesel, F. Toffoluti, V. Moreno, V. Martin, N. Aragonés, T. Dierssen-Sotos, R. Olmedo-Requena, M. Guevara, P. Amiano, D. Salas, G. Fernandez-Tardon, J. Alguacil, M.D. Chirlaque López, T. Fernandez-Villa, B. Pérez-Gómez, I. Gomez-Acebo, J.J. Jiménez-Moleón, C. Moreno-Iribas, A. José Molina, G. Castaño Vinyals, M. Pollan, M. Kogevinas, C. La Vecchia, A. Tavani. - In: EUROPEAN JOURNAL OF CANCER PREVENTION. - ISSN 0959-8278. - 30:3(2021 May 01), pp. 204-210.
Coffee consumption and colorectal cancer risk
C. La Vecchia;
2021
Abstract
This large pooled analysis of two studies shows no association of coffee and decaffeinated coffee with colorectal cancer risk. Background: Coffee contains many bioactive substances that can play a role on colorectal cancer. Epidemiological evidence of coffee intake and colorectal cancer is, however, inconsistent. Aim: To provide further information on the risk of colorectal cancer in relation to coffee consumption. Methods: Data derive from two companion case-control studies conducted in Italy and Spain within the European Union Project on Health Impacts of long-term exposure to disinfection by-products in Drinking Water and the Spanish Multi-Case Control study on Cancer. These included a total of 2289 incident cases with colorectal cancer and 3995 controls with information on coffee intake. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were derived from unconditional logistic regression models, adjusted for study centre, sex, age, education, smoking, and other covariates. Results: Compared with never coffee drinkers, the OR was 0.99 (95% CI 0.95-1.02) for total coffee consumption. There was no significant trend in risk with dose or duration, the ORs being 0.95 (95% CI 0.72-1.25) for an amount of five or more cups per day of coffee and 0.95 (95% CI 0.75-1.19) for a duration of consumption of 50 years or longer. The OR was 1.04 (95% CI 0.87-1.25) for two or more cups per day of decaffeinated coffee. There were no heterogeneity across strata of various covariates, as well as no apparent differences between various anatomical subsites. Conclusion: This large pooled analysis of two studies shows no association of coffee and decaffeinated coffee with colorectal cancer risk.File | Dimensione | Formato | |
---|---|---|---|
Coffee_consumption_and_colorectal_cancer_risk__Rosatoa.99061.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
272 kB
Formato
Adobe PDF
|
272 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Coffee_consumption_and_colorectal_cancer_risk__Rosato with pages.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
286.8 kB
Formato
Adobe PDF
|
286.8 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.