Castiglione D'Adda is one of the municipalities more precociously and severely affected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic in Lombardy. With our study we aimed to understand the diffusion of the infection by mass serological screening. We searched for SARS-CoV-2 IgGs in the entire population on a voluntary basis using lateral flow immunochromatographic tests (RICT) on capillary blood (rapid tests). We then performed chemioluminescent serological assays (CLIA) and naso-pharyngeal swabs (NPS) in a randomized representative sample and in each subject with a positive rapid test. Factors associated with RICT IgG positivity were assessed by uni- and multivariate logistic regression models. Out of the 4143 participants, 918 (22·2%) showed RICT IgG positivity. In multivariable analysis, IgG positivity increases with age, with a significant non-linear effect (p = 0·0404). We found 22 positive NPSs out of the 1330 performed. Albeit relevant, the IgG prevalence is lower than expected and suggests that a large part of the population remains susceptible to the infection. The observed differences in prevalence might reflect a different infection susceptibility by age group. A limited persistence of active infections could be found after several weeks after the epidemic peak in the area.
Prevalence of SARS-CoV-2 in an area of unrestricted viral circulation: Mass seroepidemiological screening in Castiglione d'Adda, Italy / G. Pagani, A. Giacomelli, F. Conti, D. Bernacchia, R. Rondanin, A. Prina, V. Scolari, A. Rizzo, M. Beltrami, C. Caimi, C.E. Gandolfi, S. Castaldi, B.A. Rivieccio, G. Buonanno, G. Marano, C. Ottomano, P. Boracchi, E. Biganzoli, M. Galli. - In: PLOS ONE. - ISSN 1932-6203. - 16:2(2021 Feb 24).
|Titolo:||Prevalence of SARS-CoV-2 in an area of unrestricted viral circulation: Mass seroepidemiological screening in Castiglione d'Adda, Italy|
PAGANI, GABRIELE (Co-primo) (Corresponding)
GIACOMELLI, ANDREA (Co-primo)
BIGANZOLI, ELIA (Penultimo)
GALLI, MASSIMO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||24-feb-2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1371/journal.pone.0246513|
|Appare nelle tipologie:||01 - Articolo su periodico|