In a multicenter, prospective, randomized, open-label study of isoniazid-preventive therapy (IPT) for latent tuberculosis infection, illegal immigrants from countries where tuberculosis is highly endemic were enrolled at two clinical sites in Northern Italy. Of 208 eligible subjects, 82 received supervised IPT at a close of 900 mg twice weekly for 6 mo (Regimen A), 73 received unsupervised IPT 900 mg twice weekly for 6 mo (Regimen B), and 53 received unsupervised IPT 300 mg daily for 6 mo (Regimen C). Supervised IPT was delivered at either one tuberculosis clinic or one migrant clinic. The probability of completing a 26-wk regimen was 7, 26, and 41% in Regimens A, B, and C, respectively (p ≤ 0.005, Log-rank test calculated using Kaplan-Meier plots). The mean time to dropout was 3.8, 6, and 6.2 wk in Regimens A, B, and C, respectively (p = 0.003 for regimen A versus either Regimens B or C). Treatment was stopped in five subjects (2.4%) because of adverse events. The rate of completion of preventive therapy for latent tuberculosis infection among illegal immigrants was low. Supervised, clinic-based admin stration of IPT significantly reduced adherence. Alternative strategies to implement preventive therapy in illegal immigrants are clearly required.
Supervised preventive therapy for latent tuberculosis infection in illegal immigrants in Italy / A. Matteelli, C. Casalini, M.C. Raviglione, I. El-Hamad, C. Scolari, E. Bombana, M. Bugiani, M. Caputo, C. Scarcella, G. Carosi. - In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. - ISSN 1073-449X. - 162:5(2000 Nov), pp. 1653-1655.
|Titolo:||Supervised preventive therapy for latent tuberculosis infection in illegal immigrants in Italy|
CAROSI, GIULIA (Ultimo)
|Parole Chiave:||Pulmonary and Respiratory Medicine; Critical Care and Intensive Care Medicine|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
|Data di pubblicazione:||nov-2000|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1164/ajrccm.162.5.9912062|
|Appare nelle tipologie:||01 - Articolo su periodico|