Proniosomal drug delivery system is one of the advancements in nanotechnology. Similarly to traditional dosage forms, chemical and physical compatibility of proniosomes components with the active ingredient(s) is a key step in the preformulation process of such systems. In this work, the compatibility of resveratrol with selected excipients in the development of proniosomal formulation was investigated by thermal and spectroscopic techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric study, attenuated total reflectance Fourier transform infrared spectroscopy study and powder X-ray diffraction were adopted. The results showed that the excipients used in the formulation were compatible with resveratrol.

Drug-excipients compatibility studies in proniosomal formulation: a case study with resveratrol / M. Schlich, F. Lai, A.M. Fadda, C. Sinico, E. Pini. - In: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY. - ISSN 1533-4880. - 21:5(2021 May 01), pp. 2917-2921. [10.1166/jnn.2021.19056]

Drug-excipients compatibility studies in proniosomal formulation: a case study with resveratrol

E. Pini
Ultimo
2021

Abstract

Proniosomal drug delivery system is one of the advancements in nanotechnology. Similarly to traditional dosage forms, chemical and physical compatibility of proniosomes components with the active ingredient(s) is a key step in the preformulation process of such systems. In this work, the compatibility of resveratrol with selected excipients in the development of proniosomal formulation was investigated by thermal and spectroscopic techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric study, attenuated total reflectance Fourier transform infrared spectroscopy study and powder X-ray diffraction were adopted. The results showed that the excipients used in the formulation were compatible with resveratrol.
Proniosomal formulation; resveratrol; compatibility studies; powder X-ray Diffraction; attenuated total reflectance; Fourier transform infrared spectroscopy; Differential Scanning Calorimetry;
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
Settore CHIM/06 - Chimica Organica
feb-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/817127
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