Background: The association of a solitary tumor of the pleura with paraneoplastic refractory hypoglycemia is a very rare clinical condition. Methods: An 86-year-old gentleman with an incidentally discovered large mass in the left chest and a long-standing history of refractory hypoglycemia was referred for surgical consultation. Computed tomography and PET (Positron Emission Tomography) scan confirmed the presence of a homogeneous mass leaning on the left hemidiaphragm with no tracer uptake. Results: After tumor board discussion, the mass was radically excised through a left thoracotomy. Histopathology revealed a benign solitary fibrous tumor of the pleura. At 1‑year follow-up the patient was doing well and did not further complain of hypoglycemia-related symptoms. Conclusion: Doege–Potter syndrome is a life-threatening condition associated with severely impaired quality of life. Prompt identification and surgical treatment are mandatory.

Refractory hypoglycemia associated with giant solitary fibrous tumor of the pleura (Doege–Potter syndrome) / C.A. Manzo, E. Asti, C. Froiio, B. Bruni, L. Bonavina. - In: EUROPEAN SURGERY. - ISSN 1682-8631. - 52:6(2020), pp. 296-299. [10.1007/s10353-020-00673-w]

Refractory hypoglycemia associated with giant solitary fibrous tumor of the pleura (Doege–Potter syndrome)

C.A. Manzo;E. Asti;C. Froiio;B. Bruni;L. Bonavina
2020

Abstract

Background: The association of a solitary tumor of the pleura with paraneoplastic refractory hypoglycemia is a very rare clinical condition. Methods: An 86-year-old gentleman with an incidentally discovered large mass in the left chest and a long-standing history of refractory hypoglycemia was referred for surgical consultation. Computed tomography and PET (Positron Emission Tomography) scan confirmed the presence of a homogeneous mass leaning on the left hemidiaphragm with no tracer uptake. Results: After tumor board discussion, the mass was radically excised through a left thoracotomy. Histopathology revealed a benign solitary fibrous tumor of the pleura. At 1‑year follow-up the patient was doing well and did not further complain of hypoglycemia-related symptoms. Conclusion: Doege–Potter syndrome is a life-threatening condition associated with severely impaired quality of life. Prompt identification and surgical treatment are mandatory.
Insulin-like growth factor-2; Mesothelial tumors; Neuroglycopenia; Non-islet-cell tumor-induced hypoglycemia; Whipple’s triad
Settore MED/18 - Chirurgia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/814037
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