Background: Magnetic sphincter augmentation with the Linx® system is a novel laparoscopic procedure for the treatment of gastro-esophageal reflux disease (GERD). Only few data are available regarding the impact of Linx on high-resolution manometry (HRM) variables. Methods: The prospectively collected database of patients who underwent Linx procedure at a single institution was queried. All patients who completed pre- and postoperative HRM, GERD health-related quality of life (GERD-HRQL) questionnaire, and functional outcome swallowing scale (FOSS) questionnaire were included in the study. Key Results: Forty-five out of 304 patients were included. At a median follow-up of 12 months (IQR 10) after surgery, a statistically significant increase of lower esophageal sphincter (LES) total length (P =.002), intra-abdominal length (P =.001), integrated relaxation pressure (IRP), intrabolus pressure (IBP), and esophagogastric contractile integral (EGJ-CI) was noted (P <.001). Distal esophageal amplitude (P =.004), mean distal contractile integral (DCI) (P <.001), post multiple repeated swallows DCI (P =.001), and the percent of normal peristalsis increased (P =.040). All patients were relieved of reflux symptoms. Ineffective esophageal motility reversed to normal in 36% of patients after surgery. The only factor significantly associated with postoperative dysphagia was preoperative dysphagia (P =.006). Postoperatively, a significant correlation between IRP and DCI (r = 0.361 and P =.019) and between IBP and DCI (r = 0.443 and P =.003) was found. Conclusions and Inferences: The Linx procedure had a remarkable effect on esophageal motility in the short-term follow-up. It appears that the overall postoperative increase of IRP and IBP may justify the higher DCI values. Preoperative dysphagia was the only factor associated with postoperative dysphagia.

High-resolution manometry findings after Linx procedure for gastro-esophageal reflux disease / C.G. Riva, S. Siboni, M. Sozzi, V. Lazzari, E. Asti, L. Bonavina. - In: NEUROGASTROENTEROLOGY AND MOTILITY. - ISSN 1350-1925. - 32:3(2020), pp. e13750.1-e13750.6. [10.1111/nmo.13750]

High-resolution manometry findings after Linx procedure for gastro-esophageal reflux disease

C.G. Riva;S. Siboni;M. Sozzi;V. Lazzari;E. Asti;L. Bonavina
2020

Abstract

Background: Magnetic sphincter augmentation with the Linx® system is a novel laparoscopic procedure for the treatment of gastro-esophageal reflux disease (GERD). Only few data are available regarding the impact of Linx on high-resolution manometry (HRM) variables. Methods: The prospectively collected database of patients who underwent Linx procedure at a single institution was queried. All patients who completed pre- and postoperative HRM, GERD health-related quality of life (GERD-HRQL) questionnaire, and functional outcome swallowing scale (FOSS) questionnaire were included in the study. Key Results: Forty-five out of 304 patients were included. At a median follow-up of 12 months (IQR 10) after surgery, a statistically significant increase of lower esophageal sphincter (LES) total length (P =.002), intra-abdominal length (P =.001), integrated relaxation pressure (IRP), intrabolus pressure (IBP), and esophagogastric contractile integral (EGJ-CI) was noted (P <.001). Distal esophageal amplitude (P =.004), mean distal contractile integral (DCI) (P <.001), post multiple repeated swallows DCI (P =.001), and the percent of normal peristalsis increased (P =.040). All patients were relieved of reflux symptoms. Ineffective esophageal motility reversed to normal in 36% of patients after surgery. The only factor significantly associated with postoperative dysphagia was preoperative dysphagia (P =.006). Postoperatively, a significant correlation between IRP and DCI (r = 0.361 and P =.019) and between IBP and DCI (r = 0.443 and P =.003) was found. Conclusions and Inferences: The Linx procedure had a remarkable effect on esophageal motility in the short-term follow-up. It appears that the overall postoperative increase of IRP and IBP may justify the higher DCI values. Preoperative dysphagia was the only factor associated with postoperative dysphagia.
dysphagia; gastro-esophageal reflux disease; high-resolution manometry; laparoscopic surgery; linx procedure; magnetic sphincter augmentation
Settore MED/18 - Chirurgia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/814035
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