Background: Previous studies identified alarming use of potentially inappropriate medications (PIMs) in Pakistani population but its effect on health-related quality of life (HRQoL) is still largely unknown. Objective: This study aimed to determine the association between PIMs use and HRQoL among elderly cardiac outpatients. Method: A descriptive, non-experimental, cross-sectional study was carried out from June 2018 to September 2018 in two outpatient departments of tertiary-care hospitals in the Punjab Province of Pakistan. The population under study were patients aged ≥ 65 years with at least one cardiovascular condition taking at ≥ 1 prescribed medication. Patients with PIMs were identified by using Beers criteria. HRQoL was assessed using EuroQoL-5 dimension (EQ-5D) and EuroQoL-visual analogue scale (EQ-VAS). The association of PIMs with HRQoL was analyzed using χ2 tests, independent sample t-test, and one-way ANOVA tests. Multiple linear regression analysis was used to determine how HRQoL varied by PIMs use after adjusting for patient-level covariates. Results: Of 386 elderly cardiac patients, 260 (67.4%) patients were receiving at least one PIM. Mean EQ-5D scores were significantly lower among patients with PIMs (0.51) compared to patients without PIMs (0.65) (P < 0.001). In multiple linear regression analysis, increasing numbers of PIMs were significantly associated with lower EQ-5D scores [β = − 0.040 (− 0.075, − 0.005), P < 0.001] and VAS scores [β = − 1.686 (− 2.916, − 0.456), P < 0.05]. Conclusion: The present study concluded that exposure to PIM was significantly associated with lower HRQoL. This indicates that guidelines recommendations should be followed to improve patient’s quality of life.

Potentially inappropriate medications use and its association with health-related quality of life among elderly cardiac patients / M. Saqlain, H. Ali, S. Kamran, M.U. Munir, S. Jahan, F. Mazhar. - In: QUALITY OF LIFE RESEARCH. - ISSN 0962-9343. - 29:10(2020 Oct 01), pp. 2715-2724. [10.1007/s11136-020-02530-5]

Potentially inappropriate medications use and its association with health-related quality of life among elderly cardiac patients

F. Mazhar
Ultimo
Supervision
2020

Abstract

Background: Previous studies identified alarming use of potentially inappropriate medications (PIMs) in Pakistani population but its effect on health-related quality of life (HRQoL) is still largely unknown. Objective: This study aimed to determine the association between PIMs use and HRQoL among elderly cardiac outpatients. Method: A descriptive, non-experimental, cross-sectional study was carried out from June 2018 to September 2018 in two outpatient departments of tertiary-care hospitals in the Punjab Province of Pakistan. The population under study were patients aged ≥ 65 years with at least one cardiovascular condition taking at ≥ 1 prescribed medication. Patients with PIMs were identified by using Beers criteria. HRQoL was assessed using EuroQoL-5 dimension (EQ-5D) and EuroQoL-visual analogue scale (EQ-VAS). The association of PIMs with HRQoL was analyzed using χ2 tests, independent sample t-test, and one-way ANOVA tests. Multiple linear regression analysis was used to determine how HRQoL varied by PIMs use after adjusting for patient-level covariates. Results: Of 386 elderly cardiac patients, 260 (67.4%) patients were receiving at least one PIM. Mean EQ-5D scores were significantly lower among patients with PIMs (0.51) compared to patients without PIMs (0.65) (P < 0.001). In multiple linear regression analysis, increasing numbers of PIMs were significantly associated with lower EQ-5D scores [β = − 0.040 (− 0.075, − 0.005), P < 0.001] and VAS scores [β = − 1.686 (− 2.916, − 0.456), P < 0.05]. Conclusion: The present study concluded that exposure to PIM was significantly associated with lower HRQoL. This indicates that guidelines recommendations should be followed to improve patient’s quality of life.
Cardiovascular disease; Elderly; Health related quality of life; Patient safety; Potentially inappropriate medications; Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Heart Diseases; Humans; Inappropriate Prescribing; Male; Potentially Inappropriate Medication List; Quality of Life
Settore BIO/14 - Farmacologia
20-mag-2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/814019
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