Spontaneous segregation of cholesterol and sphingolipids as a liquid-ordered phase leads to their clustering in selected membrane areas, the lipid rafts. These specialized membrane domains enriched in gangliosides, sphingomyelin, cholesterol and selected proteins involved in signal transduction, organize and determine the function of multiprotein complexes involved in several aspects of signal transduction, thus regulating cell homeostasis. Sphingosine 1-phosphate, an important biologically active mediator, is involved in several signal transduction processes regulating a plethora of cell functions and, not only several of its downstream effectors tend to localize in lipid rafts, some of the enzymes involved in its pathway, of receptors involved in its signalling and its transporters have been often found in these membrane microdomains. Considering this, in this review we address what is currently known regarding the relationship between sphingosine 1-phosphate metabolism and signalling and plasma membrane lipid rafts.
Lipid rafts as platforms for sphingosine 1-phosphate metabolism and signalling / C. D'Aprile, S. Prioni, L. Mauri, A.E.G. Prinetti, S. Grassi. - In: CELLULAR SIGNALLING. - ISSN 0898-6568. - Ebook. - 80(2021), pp. 109929.1-109929.9.
|Titolo:||Lipid rafts as platforms for sphingosine 1-phosphate metabolism and signalling|
D'APRILE, CHIARA (Primo) [Writing – Original Draft Preparation]
PRIONI, SIMONA [Writing – Original Draft Preparation]
MAURI, LAURA [Writing – Original Draft Preparation]
GRASSI, SARA (Ultimo) [Writing – Review & Editing] (Corresponding)
|Parole Chiave:||Sphingosine 1-phosphate; Lipid rafts; Sphingosine 1-phosphate receptors; Sphingosine kinase; S1P phosphatases; S1P lyase|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.cellsig.2021.109929|
|Appare nelle tipologie:||01 - Articolo su periodico|
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