Background The long-term recovery rate of chemosensitive functions in coronavirus disease 2019 patients has not yet been determined.Method A multicentre prospective study on 138 coronavirus disease 2019 patients was conducted. Olfactory and gustatory functions were prospectively evaluated for 60 days.Results Within the first 4 days of coronavirus disease 2019, 84.8 per cent of patients had chemosensitive dysfunction that gradually improved over the observation period. The most significant increase in chemosensitive scores occurred in the first 10 days for taste and between 10 and 20 days for smell. At the end of the observation period (60 days after symptom onset), 7.2 per cent of the patients still had severe dysfunctions. The risk of developing a long-lasting disorder becomes significant at 10 days for taste (odds ratio = 40.2, 95 per cent confidence interval = 2.204-733.2, p = 0.013) and 20 days for smell (odds ratio = 58.5, 95 per cent confidence interval = 3.278-1043.5, p = 0.005).Conclusion Chemosensitive disturbances persisted in 7.2 per cent of patients 60 days after clinical onset. Specific therapies should be initiated in patients with severe olfactory and gustatory disturbances 20 days after disease onset.
Smell and taste recovery in coronavirus disease 2019 patients : A 60-day objective and prospective study / L.A. Vaira, C. Hopkins, M. Petrocelli, J.R. Lechien, C.M. Chiesa-Estomba, G. Salzano, M. Cucurullo, F.A. Salzano, S. Saussez, P. Boscolo-Rizzo, F. Biglioli, G. De Riu. - In: JOURNAL OF LARYNGOLOGY AND OTOLOGY. - ISSN 0022-2151. - 134:8(2020 Aug), pp. 703-709.
|Titolo:||Smell and taste recovery in coronavirus disease 2019 patients : A 60-day objective and prospective study|
|Parole Chiave:||Ageusia; Anosmia; Coronavirus; COVID-19; Gustatory Dysfunction; Hypogeusia; SARS-CoV-2; Smell; Taste; Adult; Betacoronavirus; COVID-19; Coronavirus Infections; Female; Humans; Italy; Male; Middle Aged; Olfaction Disorders; Pandemics; Pneumonia, Viral; Prospective Studies; Recovery of Function; SARS-CoV-2; Smell; Taste; Taste Disorders|
|Settore Scientifico Disciplinare:||Settore MED/29 - Chirurgia Maxillofacciale|
|Data di pubblicazione:||ago-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1017/S0022215120001826|
|Appare nelle tipologie:||01 - Articolo su periodico|
File in questo prodotto:
|S0022215120001826.pdf||Post-print, accepted manuscript ecc. (versione accettata dall'editore)||Open Access Visualizza/Apri|
|smell-and-taste-recovery-in-coronavirus-disease-2019-patients-a-60-day-objective-and-prospective-study.pdf||Publisher's version/PDF||Open Access Visualizza/Apri|