Tumor relapse and treatment failure are unfortunately common events for cancer patients, thus often rendering cancer an uncurable disease. Cancer stem cells (CSCs) are a subset of cancer cells endowed with tumor-initiating and self-renewal capacity, as well as with high adaptive abilities. Altogether, these features contribute to CSC survival after one or multiple therapeutic approaches, thus leading to treatment failure and tumor progression/relapse. Thus, elucidating the molecular mechanisms associated with stemness-driven resistance is crucial for the development of more effective drugs and durable responses. This review will highlight the mechanisms exploited by CSCs to overcome different therapeutic strategies, from chemo-and radiotherapies to targeted therapies and immunotherapies, shedding light on their plasticity as an insidious trait responsible for their adaptation/escape. Finally, novel CSC-specific approaches will be described, providing evidence of their preclinical and clinical applications.
Cancer Stem Cells—Key Players in Tumor Relapse / M. Marzagalli, F. Fontana, M. Raimondi, P. Limonta. - In: CANCERS. - ISSN 2072-6694. - 13:3(2021), pp. 376.1-376.22.
|Titolo:||Cancer Stem Cells—Key Players in Tumor Relapse|
MARZAGALLI, MONICA (Corresponding)
|Parole Chiave:||cancer stem cells; drug resistance; molecular mechanisms; chemotherapy; radiation therapy; targeted therapies; immunotherapies|
|Settore Scientifico Disciplinare:||Settore BIO/13 - Biologia Applicata|
|Data di pubblicazione:||2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/cancers13030376|
|Appare nelle tipologie:||01 - Articolo su periodico|