The tumour-to-breast volume ratio (TBVR) is a metric that may help surgical decision making. In this retrospective Ethics-Committee–approved study, we assessed the correlation between magnetic resonance imaging (MRI)-derived TBVR and the performed surgery. The TBVR was obtained using a fully manual method for the segmentation of the tumour volume (TV) and a growing region semiautomatic method for the segmentation of the whole breast volume (WBV). Two specifically-trained residents (R1 and R2) independently segmented T1-weighted datasets of 51 cancer cases in 51 patients (median age 57 years). The intraobserver and interobserver TBVR reproducibility were calculated. Mann-Whitney U, Spearman correlations, and Bland-Altman statistics were used. Breast-conserving surgery (BCS) was performed in 31/51 cases (61%); mastectomy was performed in 20/51 cases (39%). The median TBVR was 2.08‰ (interquartile range 0.70–9.13‰) for Reader 1, and 2.28‰ (interquartile range 0.71–9.61‰) for Reader 2, with an 84% inter-reader reproducibility. The median segmentation times were 54 s for the WBV and 141 s for the TV. Significantly-lower TBVR values were observed in the breast-conserving surgery group (median 1.14‰, interquartile range 0.49–2.55‰) than in the mastectomy group (median 10.52‰, interquartile range 2.42–14.73‰) for both readers (p < 0.001). Large scale prospective studies are needed in order to validate MRI-derived TBVR as a predictor of the type of breast surgery.
MRI-Derived Tumour-to-Breast Volume Is Associated with the Extent of Breast Surgery / A. Cozzi, S. Schiaffino, G. Della Pepa, S. Carriero, V. Magni, D. Spinelli, L.A. Carbonaro, F. Sardanelli. - In: DIAGNOSTICS. - ISSN 2075-4418. - 11:2(2021).
|Titolo:||MRI-Derived Tumour-to-Breast Volume Is Associated with the Extent of Breast Surgery|
COZZI, ANDREA (Primo)
CARBONARO, LUCA ALESSANDRO (Penultimo)
SARDANELLI, FRANCESCO (Ultimo)
|Parole Chiave:||breast-conserving surgery; breast neoplasms; magnetic resonance imaging; mastectomy; tumour-to-breast volume ratio;|
|Settore Scientifico Disciplinare:||Settore MED/36 - Diagnostica per Immagini e Radioterapia|
Settore MED/06 - Oncologia Medica
|Data di pubblicazione:||2021|
|Data ahead of print / Data di stampa:||30-gen-2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/diagnostics11020204|
|Appare nelle tipologie:||01 - Articolo su periodico|
File in questo prodotto:
|Cozzi et al. - 2021 - MRI-Derived Tumour-to-Breast Volume Is Associated with the Extent of Breast Surgery.pdf||Publisher's version/PDF||Open Access Visualizza/Apri|