Background: The influence of aging and multimorbidity on Covid-19 clinical presentation is still unclear. Objectives: We investigated whether the association between symptoms (or cluster of symptoms) and positive SARS-CoV-2 nasopharyngeal swab (NPS) was different according to patients' age and presence of multimorbidity. Methods: The study included 6680 participants in the EPICOVID19 web-based survey, who reported information about symptoms from February to June 2020 and who underwent at least one NPS. Symptom clusters were identified through hierarchical cluster analysis. The associations between symptoms (and clusters of symptoms) and positive NPS were investigated through multivariable binary logistic regression in the sample stratified by age (<65 vs ≥65 years) and number of chronic diseases (0 vs 1 vs ≥2). Results: The direct association between taste/smell disorders and positive NPS was weaker in older and multimorbid patients than in their younger and healthier counterparts. Having reported no symptoms reduced the chance of positive NPS by 86% in younger (95%CI: 0.11-0.18), and by 46% in older participants (95%CI: 0.37-0.79). Of the four symptom clusters identified (asymptomatic, generic, flu-like, and combined generic and flu-like symptoms), those associated with a higher probability of SARS-CoV-2 infection were the flu-like for older people, and the combined generic and flu-like for the younger ones. Conclusions: Older age and pre-existing chronic diseases may influence the clinical presentation of Covid-19. Symptoms at disease onset tend to aggregate differently by age. New diagnostic algorithms considering age and chronic conditions may ease Covid-19 diagnosis and optimize health resources allocation.
Age-Related Changes in Clinical Presentation of Covid19: the EPICOVID19 Web-Based Survey / C. Trevisan, M. Noale, F. Prinelli, S. Maggi, A. Sojic, M. Di Bari, S. Molinaro, L. Bastiani, A. Giacomelli, M. Galli, F. Adorni, R. Antonelli Incalzi, C. Pedone. - In: EUROPEAN JOURNAL OF INTERNAL MEDICINE. - ISSN 0953-6205. - (2021). [Epub ahead of print]
|Titolo:||Age-Related Changes in Clinical Presentation of Covid19: the EPICOVID19 Web-Based Survey|
|Parole Chiave:||COVID-19; Symptom Cluster; Differential Diagnosis; Aged; European Union General Data Protection; Regulation-EU GDPR; Odds ratios ? OR; 95% confidence intervals-CIs; Multimorbidity Abbreviations SARS-CoV-2& nbsp; nasopharyngeal swab-NPS|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ejim.2021.01.028|
|Appare nelle tipologie:||01 - Articolo su periodico|