Background Atrial arrhythmias (ie, intra-atrial reentrant tachycardia and atrial fibrillation) are a leading cause of morbidity and hospitalization in adults with congenital heart disease (CHD). Little is known about their effect on quality of life and other patient-reported outcomes (PROs) in adults with CHD. Objective The purpose of this study was to assess the impact of atrial arrhythmias on PROs in adults with CHD and explore geographic variations. Methods Associations between atrial arrhythmias and PROs were assessed in a cross-sectional study of adults with CHD from 15 countries spanning 5 continents. A propensity-based matching weight analysis was performed to compare quality of life, perceived health status, psychological distress, sense of coherence, and illness perception in patients with and those without atrial arrhythmias. Results A total of 4028 adults with CHD were enrolled, 707 (17.6%) of whom had atrial arrhythmias. After applying matching weights, patients with and those without atrial arrhythmias were comparable with regard to age (mean 40.1 vs 40.2 years), demographic variables (52.5% vs 52.2% women), and complexity of CHD (15.9% simple, 44.8% moderate, and 39.2% complex in both groups). Patients with atrial arrhythmias had significantly worse PRO scores with respect to quality of life, perceived health status, psychological distress (ie, depression), and illness perception. A summary score that combines all PRO measures was significantly lower in patients with atrial arrhythmias (–3.3%; P = .0006). Differences in PROs were consistent across geographic regions. Conclusion

Atrial arrhythmias and patient-reported outcomes in adults with congenital heart disease: An international study / B. Casteigt, M. Samuel, L. Laplante, A. Shohoudi, S. Apers, A.H. Kovacs, K. Luyckx, C. Thomet, W. Budts, J. Enomoto, M.A. Sluman, C. Lu, J.L. Jackson, S.C. Cook, S. Chidambarathanu, L. Alday, K. Eriksen, M. Dellborg, M. Berghammer, B. Johansson, A.S. Mackie, S. Menahem, M. Caruana, G. Veldtman, A. Soufi, S.M. Fernandes LPD, K. White, E. Callus, S. Kutty, J. Brouillette, P. Moons, P. Khairy. - In: HEART RHYTHM. - ISSN 1547-5271. - 18:5(2021 May), pp. 793-800. [10.1016/j.hrthm.2020.09.012]

Atrial arrhythmias and patient-reported outcomes in adults with congenital heart disease: An international study

E. Callus;
2021

Abstract

Background Atrial arrhythmias (ie, intra-atrial reentrant tachycardia and atrial fibrillation) are a leading cause of morbidity and hospitalization in adults with congenital heart disease (CHD). Little is known about their effect on quality of life and other patient-reported outcomes (PROs) in adults with CHD. Objective The purpose of this study was to assess the impact of atrial arrhythmias on PROs in adults with CHD and explore geographic variations. Methods Associations between atrial arrhythmias and PROs were assessed in a cross-sectional study of adults with CHD from 15 countries spanning 5 continents. A propensity-based matching weight analysis was performed to compare quality of life, perceived health status, psychological distress, sense of coherence, and illness perception in patients with and those without atrial arrhythmias. Results A total of 4028 adults with CHD were enrolled, 707 (17.6%) of whom had atrial arrhythmias. After applying matching weights, patients with and those without atrial arrhythmias were comparable with regard to age (mean 40.1 vs 40.2 years), demographic variables (52.5% vs 52.2% women), and complexity of CHD (15.9% simple, 44.8% moderate, and 39.2% complex in both groups). Patients with atrial arrhythmias had significantly worse PRO scores with respect to quality of life, perceived health status, psychological distress (ie, depression), and illness perception. A summary score that combines all PRO measures was significantly lower in patients with atrial arrhythmias (–3.3%; P = .0006). Differences in PROs were consistent across geographic regions. Conclusion
Atrial fibrillation; Congenital heart disease; Intra-atrial reentrant tachycardia; Patient-reported outcomes; Quality of life; Atrial arrhythmias in adults with CHD are associated with an adverse impact on a broad range of PROs consistently across various geographic regions.
Settore M-PSI/08 - Psicologia Clinica
19-set-2020
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S1547527120308948-main(1).pdf

Open Access dal 20/09/2021

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 728.33 kB
Formato Adobe PDF
728.33 kB Adobe PDF Visualizza/Apri
1-s2.0-S1547527120308948-main.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 500.61 kB
Formato Adobe PDF
500.61 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/811105
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 8
social impact