Background: This study aims (I) to evaluate whether the Multidimensional Prognostic Index (MPI) score is associated with postoperative outcomes and (II) to develop a prognostic model for individual complication-risk prediction following colorectal cancer (CRC) surgery. Method: This is a prospective multicentric cohort study. Consecutive ≥75-year-old candidates for elective CRC surgery were enrolled from October 2017 to August 2019. Patients underwent standardized preoperative geriatric assessment including the MPI. Patients with MPI score > 0.33 were classified as frail. Logistic regression models were employed to evaluate variables associated with major postoperative complications and mortality, using 10-fold cross-validated LASSO (least absolute shrinkage and selection operator) for model selection. Results: In all, 104 patients were included, 34 (33%) had MPI score > 0.33. Major postoperative complications occurred in 52% of frail versus 16% of fit (MPI score ≤ 0.33) patients (p <.01). Both 30-day (9% vs. 0%; p =.033) and 90-day mortality (18% vs. 1%; p <.01) were higher among frail patients. In multivariate analysis, MPI score was associated with adverse outcomes. A final postoperative complication predictive model was created, including MPI score, gait-speed test, ASA (American Society of Anesthesiology) score, surgical approach, and stoma creation. Conclusion: MPI score is strongly associated with postoperative major complications in CRC elderly patients and it is a primary component of an individual prediction model.
Multidimensional Prognostic Index (MPI) score has the major impact on outcome prediction in elderly surgical patients with colorectal cancer: The FRAGIS study / G. Pata, L. Bianchetti, M. Rota, A. Marengoni, D. Chiesa, E. Cassinotti, S. Palmisano, M. Colombi, G. Del Zotto, G. Romanelli, S. Calza, L. Boni, N. De Manzini, U. Fumagalli Romario. - In: JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0022-4790. - 123:2(2021 Feb), pp. 667-675.
|Titolo:||Multidimensional Prognostic Index (MPI) score has the major impact on outcome prediction in elderly surgical patients with colorectal cancer: The FRAGIS study|
|Parole Chiave:||colorectal surgery; complication; frailty; geriatric assessment; multidimensional|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
|Data di pubblicazione:||feb-2021|
|Data ahead of print / Data di stampa:||25-nov-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jso.26314|
|Appare nelle tipologie:||01 - Articolo su periodico|