Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor α (RARα) locus. Investigation of20 APLs and a large series ofother neoplastic patients and normal controls revealed RARα gene rearrangements and aberrant transcripts only in the APL cases. These findings suggest that the RARα gene is involved in the APL chromosome 17 breakpoint, is implicated in leukemogenesis, and could be used as a marker for identifying leukemic promyelocytes.

Rearrangements and aberrant expression of the retinoic acid receptor α gene in acute promyelocytic leukemias / L. Longo, P.P. Pandolfi, A. Biondi, A. Rambaldi, A. Mencarelli, F.L. Coco, D. Diverio, L. Pegoraro, G. Avanzi, A. Tabilio, D. Zangrilli, M. Alcalay, E. Donti, F. Grignani, P.G. Pelicci. - In: JOURNAL OF EXPERIMENTAL MEDICINE. - ISSN 0022-1007. - 172:6(1990), pp. 1571-1575. [10.1084/jem.172.6.1571]

Rearrangements and aberrant expression of the retinoic acid receptor α gene in acute promyelocytic leukemias

A. Rambaldi;M. Alcalay;P.G. Pelicci
1990

Abstract

Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor α (RARα) locus. Investigation of20 APLs and a large series ofother neoplastic patients and normal controls revealed RARα gene rearrangements and aberrant transcripts only in the APL cases. These findings suggest that the RARα gene is involved in the APL chromosome 17 breakpoint, is implicated in leukemogenesis, and could be used as a marker for identifying leukemic promyelocytes.
Settore MED/03 - Genetica Medica
Settore MED/15 - Malattie del Sangue
Article (author)
File in questo prodotto:
File Dimensione Formato  
O5-JExpMed_Longo_90.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 510.78 kB
Formato Adobe PDF
510.78 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/810444
Citazioni
  • ???jsp.display-item.citation.pmc??? 32
  • Scopus 168
  • ???jsp.display-item.citation.isi??? 208
social impact