Exploring the role of serum lipid profile and neutrophil-to-lymphocyte ratio in violent suicide attempters: a cross sectional study

Background: Suicidality is one of the most common complications of mental disorders, so that the identification of potential biomarkers may be relevant in clinical practice. To date, the role of serum lipids and Neutrophil/Lymphocyte Ratio (NLR) has been explored albeit with conflicting results. To the best of our knowledge, no study has explored lipid levels concomitantly with NLR in relation to violent suicide attempts. Therefore, we aimed to investigate whether serum lipid levels and NLR might be associated with the violent method of suicide attempts. Methods: The study group consisted of 163 inpatients who attempted suicide. Blood samples were collected at the beginning of hospitalization to measure total cholesterol, Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL), Very-Low-Density Lipoprotein (VLDL), Triglycerides (TG) and NLR. Descriptive analyses of the total sample were performed. The included patients were divided into two groups according to violent/non-violent method. Groups were compared in terms of lipid profile and NLR using multivariate analyses of variance with gender and diagnosis as covariates (MANCOVAs).Results: Plasma levels of total cholesterol (F=5.66; p=0.02), LDL (F=4.94; p=0.03), VLDL (F=5.66; p=0.02) and NLR (F=8.17; p<0.01) resulted to be significantly lower in patients that used a violent method compared to patients who attempted suicide with a non-violent method.Conclusions: Low cholesterol, LDL and VLDL levels as well as low NLR value were associated with a violent method of suicide attempt in patients with mental disorders. Further studies are needed to confirm these results