Objective: Artificial dermal substitutes (DSs) are fundamental in physiological wound healing to ensure consistent and enduring wound closure and provide a suitable scaffold to repair tissue. We compared the clinical and histological features of two DSs, Pelnac and Integra, in the treatment of traumatic and iatrogenic skin defects. Methods: This prospective observational study involved 71 randomly selected patients from our hospital. Wound healing was analyzed using the Wound Surface Area Assessment, the Vancouver Scar Scale, and a visual analog scale. Histological and immunohistochemical evaluations were also performed. Results: At 2 weeks, greater regeneration with respect to proliferation of the epidermis and renewal of the dermis was observed with Pelnac than with Integra. At 4 weeks, the dermis had regenerated with both DSs. Both templates induced renewed collagen and revascularization. Differences in the Vancouver Scar Scale score were statistically significant at 4 weeks and 1 year. Pelnac produced a significant increase in contraction at 2 weeks with increasing effectiveness at 4 weeks. Integra produced a higher percentage reduction in the wound surface area and a shorter healing time than Pelnac for wounds >1.5 cm deep. Conclusion: Our observational data indicate that both DSs are effective and applicable in different clinical contexts.
Artificial dermal substitutes for tissue regeneration: comparison of the clinical outcomes and histological findings of two templates / F. De Francesco, A. Busato, S. Mannucci, N. Zingaretti, G. Cottone, F. Amendola, M. De Francesco, F. Merigo, V. Riccio, L. Vaienti, P.C. Parodi, A. Sbarbati, M. Riccio. - In: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH. - ISSN 0300-0605. - 48:8(2020 Aug). [10.1177/0300060520945508]
|Titolo:||Artificial dermal substitutes for tissue regeneration: comparison of the clinical outcomes and histological findings of two templates|
|Parole Chiave:||clinical study; Dermal substitutes; histological study; Integra; Pelnac; skin substitutes; tissue regeneration|
|Settore Scientifico Disciplinare:||Settore MED/19 - Chirurgia Plastica|
|Data di pubblicazione:||ago-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1177/0300060520945508|
|Appare nelle tipologie:||01 - Articolo su periodico|