Exercise perturbs homeostasis, alters the levels of circulating mediators and hormones, and increases the demand by skeletal muscles and other vital organs for energy substrates. Exercise also affects bone and mineral metabolism, particularly calcium and phosphate, both of which are essential for muscle contraction, neuromuscular signaling, biosynthesis of adenosine triphosphate (ATP), and other energy substrates. Parathyroid hormone (PTH) is involved in the regulation of calcium and phosphate homeostasis. Understanding the effects of exercise on PTH secretion is fundamental for appreciating how the body adapts to exercise. Altered PTH metabolism underlies hyperparathyroidism and hypoparathyroidism, the complications of which affect the organs involved in calcium and phosphorous metabolism (bone and kidney) and other body systems as well. Exercise affects PTH expression and secretion by altering the circulating levels of calcium and phosphate. In turn, PTH responds directly to exercise and exercise-induced myokines. Here, we review the main concepts of the regulation of PTH expression and secretion under physiological conditions, in acute and chronic exercise, and in relation to PTH-related disorders.
Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism / G. Lombardi, E. Ziemann, G. Banfi, S. Corbetta. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 21:15(2020 Jul 29), pp. 5388.1-5388.50.
|Titolo:||Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism|
CORBETTA, SABRINA LUIGIA (Ultimo) [Writing – Review & Editing]
|Parole Chiave:||PTH; calcium; hyperparathyroidism; hypoparathyroidism; irisin; osteocalcin; phosphate; physical activity; skeletal muscles; vitamin D|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Data di pubblicazione:||29-lug-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/ijms21155388|
|Appare nelle tipologie:||01 - Articolo su periodico|