P system models for mechanosensitive channels

The activity of mechanosensitive channels of large conductance (MscL, in short) in cellular membranes is modelled within the framework of P systems. These channels are gated by changes in the pressure exerted against the membrane, which may be due to natural environmental conditions (e.g., rain falling) or to a suction applied by artificial patch clamping. In correspondence to these distinct situations, we present two models for the description of MscL activation and functioning. Some fundamental components of P systems are introduced, such as multiple membrane labelling, a variable parameter for membrane tension, concentrations of objects, concentration based rules and environmental rules with associated probabilities. We present simulations in silico of one model and show the emergent behavior of fundamental quanitites. Finally, we discuss several topics for further extensions and development of these models.