Auditory verbal hallucinations (AVHs) are defined as verbal perceptions without an objective provoking external stimulus. AVHs are core symptoms of schizophrenia and psychotic spectrum disorders and have a wide prevalence in other severe psychiatric disorders including affective disorders and substance-use disorders. Despite adequate pharmacological treatment, AVHs can persist over the long-term course of these disorders in a significant percentage of patients, causing significant individual impairment. Noninvasive brain stimulation interventions represent a new frontier in the investigation and development of novel treatment options for both schizophrenia and psychotic spectrum disorders. In particular, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have been used in the treatment of AVHs in the last two decades. These techniques have the common feature of delivering electrical energy to the brain from an external source, as happens with tDCS, or through the induction of magnetic fields, as the case of repetitive TMS. The electrical stimulation is aimed to produce an excitation or inhibition of specific functional neuro-circuits that are involved in the pathogenesis of AVHs. In this chapter, we summarized main evidence in relation to the therapeutic use of the above-mentioned approaches in patients with AVHs, with specific attention to the recommendations of available international guidelines. Current major limitations and possible future perspectives are discussed as well.

Innovative approaches to hallucinations in psychosis and affective disorders: A focus on noninvasive brain stimulation interventions / B. Dell'Osso, M. Carlotta Palazzo, A.C. Altamura - In: Hallucinations in psychoses and affective disorders : a clinical and biological approach / [a cura di] P. Brambilla, M.C. Mauri, A.C. Altamura. - [s.l] : Springer, 2018. - ISBN 9783319751238. - pp. 191-208 [10.1007/978-3-319-75124-5_12]

Innovative approaches to hallucinations in psychosis and affective disorders: A focus on noninvasive brain stimulation interventions

B. Dell'Osso;A.C. Altamura
2018

Abstract

Auditory verbal hallucinations (AVHs) are defined as verbal perceptions without an objective provoking external stimulus. AVHs are core symptoms of schizophrenia and psychotic spectrum disorders and have a wide prevalence in other severe psychiatric disorders including affective disorders and substance-use disorders. Despite adequate pharmacological treatment, AVHs can persist over the long-term course of these disorders in a significant percentage of patients, causing significant individual impairment. Noninvasive brain stimulation interventions represent a new frontier in the investigation and development of novel treatment options for both schizophrenia and psychotic spectrum disorders. In particular, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have been used in the treatment of AVHs in the last two decades. These techniques have the common feature of delivering electrical energy to the brain from an external source, as happens with tDCS, or through the induction of magnetic fields, as the case of repetitive TMS. The electrical stimulation is aimed to produce an excitation or inhibition of specific functional neuro-circuits that are involved in the pathogenesis of AVHs. In this chapter, we summarized main evidence in relation to the therapeutic use of the above-mentioned approaches in patients with AVHs, with specific attention to the recommendations of available international guidelines. Current major limitations and possible future perspectives are discussed as well.
Noninvasive Brain Stimulation; Auditory Verbal Hallucinations (AVHs); Psychotic Spectrum Disorders; Transcranial Magnetic Stimulation (TMS); Positive And Negative Syndrome Scale (PANSS)
Settore MED/25 - Psichiatria
2018
Book Part (author)
File in questo prodotto:
File Dimensione Formato  
29 aug DellOsso Brain Stim for Hallucination.pdf

accesso riservato

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 507.34 kB
Formato Adobe PDF
507.34 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
DellOsso2018_Chapter_InnovativeApproachesToHallucin.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 547.37 kB
Formato Adobe PDF
547.37 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/802773
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact