The highly conserved DNA polymerase α-primase complex (pol-prim) is the only eukaryotic DNA polymerase that can initiate DNA synthesis de novo. It is required both for the initiation of DNA replication at chromosomal origins and for the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. The dual role of pol-prim makes it a likely target for mechanisms that control cell-cycle S-phase entry and progression.

The DNA polymerase α-primase complex couples DNA replication, cell- cycle progression and DNA-damage response / M. Foiani, G. Lucchini, P. Plevani. - In: TRENDS IN BIOCHEMICAL SCIENCES. - ISSN 0968-0004. - 22:11(1997), pp. 424-427. [10.1016/S0968-0004(97)01109-2]

The DNA polymerase α-primase complex couples DNA replication, cell- cycle progression and DNA-damage response

M. Foiani
Primo
;
P. Plevani
Ultimo
1997

Abstract

The highly conserved DNA polymerase α-primase complex (pol-prim) is the only eukaryotic DNA polymerase that can initiate DNA synthesis de novo. It is required both for the initiation of DNA replication at chromosomal origins and for the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. The dual role of pol-prim makes it a likely target for mechanisms that control cell-cycle S-phase entry and progression.
Budding yeast; B-subunit; protein-A; in-vitro; S-phase; initiation; mechanism; phosphorylation; fork; vivo
Settore BIO/11 - Biologia Molecolare
1997
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/802335
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