The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.

A model of DNA damage response activation at stalled replication forks by SPRTN / C. Bruhn, M. Foiani. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 10:1(2019), pp. 5671.1-5671.3. [10.1038/s41467-019-13610-7]

A model of DNA damage response activation at stalled replication forks by SPRTN

M. Foiani
Ultimo
2019

Abstract

The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.
Cell Cycle; Checkpoint Kinase 1; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; Genomic Instability; Humans
Settore BIO/11 - Biologia Molecolare
2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/801726
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