We assessed the effect of surgical aortic valve replacement (SAVR) on cardiovascular and cerebrovascular controls with particular attention to their complexity and presence of nonlinear behaviors via the analysis of spontaneous variability of heart period (HP), systolic and diastolic arterial pressure (SAP and DAP) and mean cerebral blood flow (MCBF). Variability series were acquired before (PRE) and after (POST) SAVR in 12 patients (age: 76±4.7 yrs, 7 males) at rest in supine position and during active standing. Complexity was assessed via a local nonlinear prediction approach exploiting the k-nearest neighbor strategy. The presence of nonlinear dynamics was checked by comparing the complexity marker computed over the original series with the distribution of values assessed over 100 surrogates preserving distribution and power spectral density of the original series but with random phases. We found that: i) HP variance was significantly reduced in POST; ii) the complexity of SAP and DAP variabilities increased in POST with a greater likelihood of observing nonlinear dynamics over SAP compared to PRE at supine rest; iii) the amplitude of MCBF fluctuations and its complexity in POST remained similar to PRE. SAVR induces important changes of the cardiac and vascular autonomic controls, while cerebrovascular regulation seems to be less affected.

Complexity and nonlinearities of short-term cardiovascular and cerebrovascular controls after surgical aortic valve replacement / A. Porta, A. Fantinato, V. Bari, B. Cairo, B. De Maria, E. Giuseppe Bertoldo, V. Fiolo, E. Callus, C. De Vincentiis, M. Volpe, R. Molfetta, M. Ranucci - In: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)[s.l] : IEEE, 2020. - ISBN 9781728119915. - pp. 2569-2572 (( Intervento presentato al 42. convegno Annual International Conferences of the IEEE Engineering in Medicine and Biology Society tenutosi a Montreal nel 2020.

Complexity and nonlinearities of short-term cardiovascular and cerebrovascular controls after surgical aortic valve replacement

A. Porta
Primo
;
V. Bari;B. Cairo;E. Callus;
2020

Abstract

We assessed the effect of surgical aortic valve replacement (SAVR) on cardiovascular and cerebrovascular controls with particular attention to their complexity and presence of nonlinear behaviors via the analysis of spontaneous variability of heart period (HP), systolic and diastolic arterial pressure (SAP and DAP) and mean cerebral blood flow (MCBF). Variability series were acquired before (PRE) and after (POST) SAVR in 12 patients (age: 76±4.7 yrs, 7 males) at rest in supine position and during active standing. Complexity was assessed via a local nonlinear prediction approach exploiting the k-nearest neighbor strategy. The presence of nonlinear dynamics was checked by comparing the complexity marker computed over the original series with the distribution of values assessed over 100 surrogates preserving distribution and power spectral density of the original series but with random phases. We found that: i) HP variance was significantly reduced in POST; ii) the complexity of SAP and DAP variabilities increased in POST with a greater likelihood of observing nonlinear dynamics over SAP compared to PRE at supine rest; iii) the amplitude of MCBF fluctuations and its complexity in POST remained similar to PRE. SAVR induces important changes of the cardiac and vascular autonomic controls, while cerebrovascular regulation seems to be less affected.
Settore ING-INF/06 - Bioingegneria Elettronica e Informatica
Settore M-PSI/08 - Psicologia Clinica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/801403
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