Morphea is a rare sclerotic autoimmune disorder primary affecting the skin and subcutaneous tissues. The linear head variants involve the facial area, with asymmetries and deformities. Eighteen patients with hemifacial deformity (age range 14–75 years) were assessed before surgery (T0), and after one (T1, 18 patients) or two (T2, six patients) surgical treatments of facial autologous fat grafting. A stereophotogrammetric reconstruction of the facial surface was obtained for each patient and a group of control subjects, and facial symmetry was quantified according to the root mean square distance between homologous areas of trigeminal innervation. Values obtained from the control subjects were used to calculate z-scores for patients. At T0, all facial thirds of the patients resulted significantly more asymmetrical than those of the control subjects (Mann–Whitney test, p < 0.05), while at T1, the symmetry of the middle facial third did not differ from that of control subjects (p = 0.263). At T2, the upper and the lower facial thirds also did not differ from the control values (p > 0.05). The faster result obtained in the facial middle third was in accord with clinical findings. In conclusion, autologous fat grafting significantly improved facial asymmetry after one (middle facial third) or two (lower and upper thirds) treatments; the outcomes were efficaciously quantified by stereophotogrammetry.

Efficacy of autologous fat grafting in restoring facial symmetry in linear morphea-associated lesions / C. Baserga, A. Cappella, D.M. Gibelli, R. Sacco, C. Dolci, F. Cullati, A.B. Gianni, C. Sforza. - In: SYMMETRY. - ISSN 2073-8994. - 12:12(2020), pp. 2098.1-2098.13. [10.3390/sym12122098]

Efficacy of autologous fat grafting in restoring facial symmetry in linear morphea-associated lesions

C. Baserga
Co-primo
;
A. Cappella
Co-primo
;
D.M. Gibelli
Secondo
;
C. Dolci;A.B. Gianni
Penultimo
;
C. Sforza
Ultimo
2020

Abstract

Morphea is a rare sclerotic autoimmune disorder primary affecting the skin and subcutaneous tissues. The linear head variants involve the facial area, with asymmetries and deformities. Eighteen patients with hemifacial deformity (age range 14–75 years) were assessed before surgery (T0), and after one (T1, 18 patients) or two (T2, six patients) surgical treatments of facial autologous fat grafting. A stereophotogrammetric reconstruction of the facial surface was obtained for each patient and a group of control subjects, and facial symmetry was quantified according to the root mean square distance between homologous areas of trigeminal innervation. Values obtained from the control subjects were used to calculate z-scores for patients. At T0, all facial thirds of the patients resulted significantly more asymmetrical than those of the control subjects (Mann–Whitney test, p < 0.05), while at T1, the symmetry of the middle facial third did not differ from that of control subjects (p = 0.263). At T2, the upper and the lower facial thirds also did not differ from the control values (p > 0.05). The faster result obtained in the facial middle third was in accord with clinical findings. In conclusion, autologous fat grafting significantly improved facial asymmetry after one (middle facial third) or two (lower and upper thirds) treatments; the outcomes were efficaciously quantified by stereophotogrammetry.
Face; Facial asymmetry; Facial hemiatrophy; Linear morphea; Lipofilling; Localized; Scleroderma; Stereophotogrammetry; Treatment outcome
Settore BIO/16 - Anatomia Umana
Settore MED/29 - Chirurgia Maxillofacciale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/800854
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