Mortality in an italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests

Introduction: The COVID-19 pandemic caused an increased mortality in nursing homes due to its quickspreadand the age-related high lethality.Results: We observed a two-month mortality of 40%, compared to 6.4% in the previous year. This increasewasseen in both COVID-19 positive (43%) and negative (24%) residents, but 8 patients among thosetestingnegative on the swab, tested positive on serological tests. Increased mortality was associated withmalegender, older age, no previous vitamin D supplementation and worse “activities of daily living (ADL)”scores,such as Barthel index, Tinetti scale and S.OS.I.A. classification.Conclusion: Our data confirms a higher geriatric mortality due to COVID-19. Negative residents also had highermortality, which we suspect is secondary to preanalytical error and a low sensitivity of the swab test in poorlycompliant subjects. Male gender, older age and low scores on ADL scales (probably due to immobility) areriskfactors for COVID-19 related mortality. Finally, mortality was inversely associated with vitaminDsupplementation.Design: In this observational study, we described the two-month mortality among the 157 residents (age 60-100) of a nursing home after Sars-CoV-2 spreading, reporting the factors associated with the outcome. Wealsocompared the diagnostic tests for Sars-CoV-2.