We retrospectively investigated, in 62 consecutive hospitalised COVID-19 patients (aged 70 ± 14 years, 40 males), the prognostic value of CT-derived subcutaneous adipose tissue and visceral adipose tissue (VAT) metrics, testing them in four predictive models for admission to intensive care unit (ICU), with and without pre-existing comorbidities. Multivariate logistic regression identified VAT score as the best ICU admission predictor (odds ratios 4.307–12.842). A non-relevant contribution of comorbidities at receiver operating characteristic analysis (area under the curve 0.821 for the CT-based model, 0.834 for the one including comorbidities) highlights the potential one-stop-shop prognostic role of CT-derived lung and adipose tissue metrics.

Visceral adipose tissue area predicts intensive care unit admission in COVID-19 patients / F. Pediconi, V. Rizzo, S. Schiaffino, A. Cozzi, G. Della Pepa, F. Galati, C. Catalano, F. Sardanelli. - In: OBESITY RESEARCH & CLINICAL PRACTICE. - ISSN 1871-403X. - (2020). [Epub ahead of print] [10.1016/j.orcp.2020.12.002]

Visceral adipose tissue area predicts intensive care unit admission in COVID-19 patients

A. Cozzi;G. DELLA PEPA;F. Sardanelli
Ultimo
2020

Abstract

We retrospectively investigated, in 62 consecutive hospitalised COVID-19 patients (aged 70 ± 14 years, 40 males), the prognostic value of CT-derived subcutaneous adipose tissue and visceral adipose tissue (VAT) metrics, testing them in four predictive models for admission to intensive care unit (ICU), with and without pre-existing comorbidities. Multivariate logistic regression identified VAT score as the best ICU admission predictor (odds ratios 4.307–12.842). A non-relevant contribution of comorbidities at receiver operating characteristic analysis (area under the curve 0.821 for the CT-based model, 0.834 for the one including comorbidities) highlights the potential one-stop-shop prognostic role of CT-derived lung and adipose tissue metrics.
Intra-Abdominal fat; Subcutaneous fat; Tomography, X-Ray computed; COVID-19; Severe acute respiratory syndrome coronavirus 2; Critical care;
Settore MED/36 - Diagnostica per Immagini e Radioterapia
11-dic-2020
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S1871403X20306219-main.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 674.38 kB
Formato Adobe PDF
674.38 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/800612
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 12
social impact