Controlled ovarian hyperstimulation (COH) determines an anticipation of endometrial maturation and a premature occurrence of the implantation window, as shown by histological, histochemical, and molecular studies and indirectly by clinical trials. There is growing agreement that in patients hyper-responding to COH and in those undergoing transfer at the blastocyst stage, deferring the transfer in a subsequent frozen cycle could increase pregnancy outcomes. For blastocysts, implantation after a fresh transfer may be limited as the implantation window is already closed while, in hyper-responders to COH, the anticipation magnitude could be more marked thus hampering implantation also for cleavage-stage embryos. Research should focus in depth on pregnancy outcomes and on the most suitable modality to prepare the endometrium for frozen transfers.
Frozen IVF Cycles to Circumvent the Hormonal Storm on Endometrium / P. Vigano, A. Alteri, A. Busnelli, V.S. Vanni, E. Somigliana. - In: TRENDS IN ENDOCRINOLOGY AND METABOLISM. - ISSN 1043-2760. - 31:4(2020 Apr), pp. 296-307.
|Titolo:||Frozen IVF Cycles to Circumvent the Hormonal Storm on Endometrium|
SOMIGLIANA, EDGARDO (Ultimo)
|Parole Chiave:||controlled ovarian hyperstimulation; endometrium; frozen cycles; IVF|
|Settore Scientifico Disciplinare:||Settore MED/40 - Ginecologia e Ostetricia|
|Data di pubblicazione:||apr-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.tem.2020.01.009|
|Appare nelle tipologie:||01 - Articolo su periodico|