The effect of an acidic factor of low molecular weight (about 1,000 daltons), extracted from bovine spermatozoan DNA, on the inducibility of δ-aminolevulinic acid synthase by ethanol during aging in rat has been examined. The increased enzyme inducibility in 600-day old rats is supported by stimulation of transcriptional and translational processes; on the contrary, in 30-day old rats, the higher enzyme values induced by ethanol are significantly decreased after factor treatment. The active factor is strongly DNA-bound in the native spermatozoan DNA. This would imply a possible role in regulating gene expression in vivo.
A non-steroidal gametic factor linked to DNA modulates δ-aminolevulinic acid synthase inducibility acting on liver transcriptional and translational processes / G. Lugaro, E. Manera, M.M. Casellato, L. Riboni. - In: EXPERIMENTAL GERONTOLOGY. - ISSN 0531-5565. - 17:5(1982), pp. 365-373. [10.1016/0531-5565(82)90036-5]
A non-steroidal gametic factor linked to DNA modulates δ-aminolevulinic acid synthase inducibility acting on liver transcriptional and translational processes
L. Riboni
1982
Abstract
The effect of an acidic factor of low molecular weight (about 1,000 daltons), extracted from bovine spermatozoan DNA, on the inducibility of δ-aminolevulinic acid synthase by ethanol during aging in rat has been examined. The increased enzyme inducibility in 600-day old rats is supported by stimulation of transcriptional and translational processes; on the contrary, in 30-day old rats, the higher enzyme values induced by ethanol are significantly decreased after factor treatment. The active factor is strongly DNA-bound in the native spermatozoan DNA. This would imply a possible role in regulating gene expression in vivo.
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