BACKGROUND AND AIM OF WORK: Lung microwave ablation (MWA) is considered an alternative treatment in high-risk patients, not suitable for surgery. The aim of our study is to compare MWA and pulmonary lobectomy in high-risk, lung cancer patients. METHODS: This was a single-center, propensity score--weighted cohort study. All adult patients who underwent CT guided MWA for stage I NSCLC between June 2009-October 2014 were included in the study and were compared with a cohort of patients submitted to lung lobectomy in the same period of time. Outcomes were overall survival (OS) and disease-free survival (DFS). RESULTS: 32 patients underwent MWA, and 35 high-risk patients submitted to lung lobectomy in the same period were selected. Median follow-up time was 51.1 months (95% CI: 43.8-62.3). Overall survival was 43.8 (95% CI: 26.1-55) and 55.8 months (95% CI: 49.9-76.8) in the MWA group and Lobectomy group, respectively. Negative prognostic factors were MWA procedure (HR:2.25, 95% CI: 1.20-4.21, p= 0.0109) and nodule diameter (HR: 1.04, 95% CI: 1.01-1.07; p= 0.007) for OS, while MWA procedure (HR: 5.2; 95% CI: 2.1-12.8: p < 0.001), ECOG 3 (HR: 5.0; 95% CI: 1.6-15.6; p = 0.006) and nodule diameter (HR: 1.1; 95% CI: 1.0-1.1; p = 0.003) for DFS. CONCLUSIONS: Our study demonstrated a high percentage of local relapse in the MWA group but a comparable overall survival. Although lung lobectomy remains the gold standard treatment for stage I NSCLC, we can consider the MWA procedure as valid alternative local treatment in high-risk patients for stage I NSCLC.
Percutaneous lung microwave ablation versus lung resection in high-risk patients. A monocentric experience / P. Mendogni, E. Daffre, L. Rosso, A. Palleschi, I. Righi, R. Carrinola, F. Damarco, F. Polli, A. Ierardi, A. Arrichiello, G. Carrafiello, M. Nosotti, D. Tosi. - In: ACTA BIOMEDICA. - ISSN 2531-6745. - 91:10 Suppl.(2020 Sep 23).
|Titolo:||Percutaneous lung microwave ablation versus lung resection in high-risk patients. A monocentric experience|
|Settore Scientifico Disciplinare:||Settore MED/21 - Chirurgia Toracica|
Settore MED/36 - Diagnostica per Immagini e Radioterapia
|Data di pubblicazione:||23-set-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.23750/abm.v91i10-S.10342|
|Appare nelle tipologie:||01 - Articolo su periodico|