LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky, N.; Almouzni, G.; Gorski, S.A.; Aerts, S.; Amit, I.; Bertero, M.G.; Bock, C.; Bredenoord, A.L.; Cavalli, G.; Chiocca, S.; Clevers, H.; De Strooper, B.; Eggert, A.; Ellenberg, J.; Fernandez, X.M.; Figlerowicz, M.; Gasser, S.M.; Hubner, N.; Kjems, J.; Knoblich, J.A.; Krabbe, G.; Lichter, P.; Linnarsson, S.; Marine, J.-.; Marioni, J.; Marti-Renom, M.A.; Netea, M.G.; Nickel, D.; Nollmann, M.; Novak, H.R.; Parkinson, H.; Piccolo, S.; Pinheiro, I.; Pombo, A.; Popp, C.; Reik, W.; Roman-Roman, S.; Rosenstiel, P.; Schultze, J.L.; Stegle, O.; Tanay, A.; Testa, G.; Thanos, D.; Theis, F.J.; Torres-Padilla, M.-.; Valencia, A.; Vallot, C.; van Oudenaarden, A.; Vidal, M.; Voet, T.; Alberi, L.; Alexander, S.; Alexandrov, T.; Arenas, E.; Bagni, C.; Balderas, R.; Bandelli, A.; Becher, B.; Becker, M.; Beerenwinkel, N.; Benkirame, M.; Beyer, M.; Bickmore, W.; Biessen, E.E.A.L.; Blomberg, N.; Blumcke, I.; Bodenmiller, B.; Borroni, B.; Boumpas, D.T.; Bourgeron, T.; Bowers, S.; Braeken, D.; Brooksbank, C.; Brose, N.; Bruining, H.; Bury, J.; Caporale, N.; Cattoretti, G.; Chabane, N.; Chneiweiss, H.; Cook, S.A.; Curatolo, P.; de Jonge, M.I.; Deplancke, B.; De Strooper, B.; de Witte, P.; Dimmeler, S.; Draganski, B.; Drews, A.-.; Dumbrava, C.; Engelhardt, S.; Gasser, T.; Giamarellos-Bourboulis, E.J.; Graff, C.; Grun, D.; Gut, I.; Hansson, O.; Henshall, D.C.; Herland, A.; Heutink, P.; Heymans, S.R.B.; Heyn, H.; Huch, M.; Huitinga, I.; Jackowiak, P.; Jongsma, K.R.; Journot, L.; Junker, J.P.; Katz, S.; Kehren, J.; Kempa, S.; Kirchhof, P.; Klein, C.; Koralewska, N.; Korbel, J.O.; Kuhnemund, M.; Lamond, A.I.; Lauwers, E.; Le Ber, I.; Leinonen, V.; Tobon, A.L.; Lundberg, E.; Lunkes, A.; Maatz, H.; Mann, M.; Marelli, L.; Matser, V.; Matthews, P.M.; Mechta-Grigoriou, F.; Menon, R.; Nielsen, A.F.; Pagani, M.; Pasterkamp, R.J.; Pitkanen, A.; Popescu, V.; Pottier, C.; Puisieux, A.; Rademakers, R.; Reiling, D.; Reiner, O.; Remondini, D.; Ritchie, C.; Rohrer, J.D.; Saliba, A.-.; Sanchez-Valle, R.; Santosuosso, A.; Sauter, A.; Scheltema, R.A.; Scheltens, P.; Schiller, H.B.; Schneider, A.; Seibler, P.; Sheehan-Rooney, K.; Shields, D.; Sleegers, K.; Smit, G.; Smith, K.G.C.; Smolders, I.; Synofzik, M.; Tam, W.L.; Teichmann, S.; Thom, M.; Turco, M.Y.; van Beusekom, H.M.M.; Vandenberghe, R.; den Hoecke, S.V.; Van de Poel, I.; der Ven, A.; van der Zee, J.; van Lunzen, J.; van Minnebruggen, G.; van Oudenaarden, A.; Van Paesschen, W.; van Swieten, J.; van Vught, R.; Verhage, M.; Verstreken, P.; Villa, C.E.; Vogel, J.; von Kalle, C.; Walter, J.; Weckhuysen, S.; Weichert, W.; Wood, L.; Ziegler, A.-.; Zipp, F.

doi:10.1038/s41586-020-2715-9

LifeTime aims to track, understand and target human cells during the onset and progression of complex diseases and their response to therapy at single-cell resolution. This mission will be implemented through the development and integration of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during progression from health to disease. Analysis of such large molecular and clinical datasets will discover molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. Timely detection and interception of disease embedded in an ethical and patient-centered vision will be achieved through interactions across academia, hospitals, patient-associations, health data management systems and industry. Applying this strategy to key medical challenges in cancer, neurological, infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.

LifeTime and improving European healthcare through cell-based interceptive medicine / N. Rajewsky, G. Almouzni, S.A. Gorski, S. Aerts, I. Amit, M.G. Bertero, C. Bock, A.L. Bredenoord, G. Cavalli, S. Chiocca, H. Clevers, B. De Strooper, A. Eggert, J. Ellenberg, X.M. Fernandez, M. Figlerowicz, S.M. Gasser, N. Hubner, J. Kjems, J.A. Knoblich, G. Krabbe, P. Lichter, S. Linnarsson, J.-. Marine, J. Marioni, M.A. Marti-Renom, M.G. Netea, D. Nickel, M. Nollmann, H.R. Novak, H. Parkinson, S. Piccolo, I. Pinheiro, A. Pombo, C. Popp, W. Reik, S. Roman-Roman, P. Rosenstiel, J.L. Schultze, O. Stegle, A. Tanay, G. Testa, D. Thanos, F.J. Theis, M.-. Torres-Padilla, A. Valencia, C. Vallot, A. van Oudenaarden, M. Vidal, T. Voet, L. Alberi, S. Alexander, T. Alexandrov, E. Arenas, C. Bagni, R. Balderas, A. Bandelli, B. Becher, M. Becker, N. Beerenwinkel, M. Benkirame, M. Beyer, W. Bickmore, E.E.A.L. Biessen, N. Blomberg, I. Blumcke, B. Bodenmiller, B. Borroni, D.T. Boumpas, T. Bourgeron, S. Bowers, D. Braeken, C. Brooksbank, N. Brose, H. Bruining, J. Bury, N. Caporale, G. Cattoretti, N. Chabane, H. Chneiweiss, S.A. Cook, P. Curatolo, M.I. de Jonge, B. Deplancke, B. De Strooper, P. de Witte, S. Dimmeler, B. Draganski, A.-. Drews, C. Dumbrava, S. Engelhardt, T. Gasser, E.J. Giamarellos-Bourboulis, C. Graff, D. Grun, I. Gut, O. Hansson, D.C. Henshall, A. Herland, P. Heutink, S.R.B. Heymans, H. Heyn, M. Huch, I. Huitinga, P. Jackowiak, K.R. Jongsma, L. Journot, J.P. Junker, S. Katz, J. Kehren, S. Kempa, P. Kirchhof, C. Klein, N. Koralewska, J.O. Korbel, M. Kuhnemund, A.I. Lamond, E. Lauwers, I. Le Ber, V. Leinonen, A.L. Tobon, E. Lundberg, A. Lunkes, H. Maatz, M. Mann, L. Marelli, V. Matser, P.M. Matthews, F. Mechta-Grigoriou, R. Menon, A.F. Nielsen, M. Pagani, R.J. Pasterkamp, A. Pitkanen, V. Popescu, C. Pottier, A. Puisieux, R. Rademakers, D. Reiling, O. Reiner, D. Remondini, C. Ritchie, J.D. Rohrer, A.-. Saliba, R. Sanchez-Valle, A. Santosuosso, A. Sauter, R.A. Scheltema, P. Scheltens, H.B. Schiller, A. Schneider, P. Seibler, K. Sheehan-Rooney, D. Shields, K. Sleegers, G. Smit, K.G.C. Smith, I. Smolders, M. Synofzik, W.L. Tam, S. Teichmann, M. Thom, M.Y. Turco, H.M.M. van Beusekom, R. Vandenberghe, S.V. den Hoecke, I. Van de Poel, A. der Ven, J. van der Zee, J. van Lunzen, G. van Minnebruggen, A. van Oudenaarden, W. Van Paesschen, J. van Swieten, R. van Vught, M. Verhage, P. Verstreken, C.E. Villa, J. Vogel, C. von Kalle, J. Walter, S. Weckhuysen, W. Weichert, L. Wood, A.-. Ziegler, F. Zipp. - In: NATURE. - ISSN 0028-0836. - 587:7834(2020), pp. 377-386. [10.1038/s41586-020-2715-9]

LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky N.;Almouzni G.;Gorski S. A.;Aerts S.;Amit I.;Bertero M. G.;Bock C.;Bredenoord A. L.;Cavalli G.;Chiocca S.;Clevers H.;De Strooper B.;Eggert A.;Ellenberg J.;Fernandez X. M.;Figlerowicz M.;Gasser S. M.;Hubner N.;Kjems J.;Knoblich J. A.;Krabbe G.;Lichter P.;Linnarsson S.;Marine J. -C.;Marioni J.;Marti-Renom M. A.;Netea M. G.;Nickel D.;Nollmann M.;Novak H. R.;Parkinson H.;Piccolo S.;Pinheiro I.;Pombo A.;Popp C.;Reik W.;Roman-Roman S.;Rosenstiel P.;Schultze J. L.;Stegle O.;Tanay A.;G. Testa^{Conceptualization};Thanos D.;Theis F. J.;Torres-Padilla M. -E.;Valencia A.;Vallot C.;van Oudenaarden A.;Vidal M.;Voet T.;Alberi L.;Alexander S.;Alexandrov T.;Arenas E.;Bagni C.;Balderas R.;Bandelli A.;Becher B.;Becker M.;Beerenwinkel N.;Benkirame M.;Beyer M.;Bickmore W.;Biessen E. E. A. L.;Blomberg N.;Blumcke I.;Bodenmiller B.;Borroni B.;Boumpas D. T.;Bourgeron T.;Bowers S.;Braeken D.;Brooksbank C.;Brose N.;Bruining H.;Bury J.;N. Caporale^{Conceptualization};Cattoretti G.;Chabane N.;Chneiweiss H.;Cook S. A.;Curatolo P.;de Jonge M. I.;Deplancke B.;De Strooper B.;de Witte P.;Dimmeler S.;Draganski B.;Drews A. -D.;Dumbrava C.;Engelhardt S.;Gasser T.;Giamarellos-Bourboulis E. J.;Graff C.;Grun D.;Gut I.;Hansson O.;Henshall D. C.;Herland A.;Heutink P.;Heymans S. R. B.;Heyn H.;Huch M.;Huitinga I.;Jackowiak P.;Jongsma K. R.;Journot L.;Junker J. P.;Katz S.;Kehren J.;Kempa S.;Kirchhof P.;Klein C.;Koralewska N.;Korbel J. O.;Kuhnemund M.;Lamond A. I.;Lauwers E.;Le Ber I.;Leinonen V.;Tobon A. L.;Lundberg E.;Lunkes A.;Maatz H.;Mann M.;L. Marelli;Matser V.;Matthews P. M.;Mechta-Grigoriou F.;Menon R.;Nielsen A. F.;M. Pagani;Pasterkamp R. J.;Pitkanen A.;Popescu V.;Pottier C.;Puisieux A.;Rademakers R.;Reiling D.;Reiner O.;Remondini D.;Ritchie C.;Rohrer J. D.;Saliba A. -E.;Sanchez-Valle R.;Santosuosso A.;Sauter A.;Scheltema R. A.;Scheltens P.;Schiller H. B.;Schneider A.;Seibler P.;Sheehan-Rooney K.;Shields D.;Sleegers K.;Smit G.;Smith K. G. C.;Smolders I.;Synofzik M.;Tam W. L.;Teichmann S.;Thom M.;M.Y. Turco;van Beusekom H. M. M.;Vandenberghe R.;den Hoecke S. V.;Van de Poel I.;der Ven A.;van der Zee J.;van Lunzen J.;van Minnebruggen G.;van Oudenaarden A.;Van Paesschen W.;van Swieten J.;van Vught R.;Verhage M.;Verstreken P.;Villa C. E.;Vogel J.;von Kalle C.;Walter J.;Weckhuysen S.;Weichert W.;Wood L.;Ziegler A. -G.;Zipp F.

2020

Abstract

LifeTime aims to track, understand and target human cells during the onset and progression of complex diseases and their response to therapy at single-cell resolution. This mission will be implemented through the development and integration of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during progression from health to disease. Analysis of such large molecular and clinical datasets will discover molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. Timely detection and interception of disease embedded in an ethical and patient-centered vision will be achieved through interactions across academia, hospitals, patient-associations, health data management systems and industry. Applying this strategy to key medical challenges in cancer, neurological, infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.

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Scheda completa (DC)

	Settori scientifico-disciplinari dell'articolo (sola visualizzazione)
	
				Settore BIO/11 - Biologia Molecolare
Settore BIO/13 - Biologia Applicata
Settore MED/03 - Genetica Medica
			
	Titolo del progetto
	
	Titolo Progetto
	
									Revolutionizing Healthcare by Tracking and Understanding Human Cells during Disease (LifeTime)
								
	Acronimo
	
									LifeTime
								
	Nome finanziatore
	
										EUROPEAN COMMISSION
									
	Finanziamento
	
									H2020
								
	N. Contratto
	
									820431
								
	Data di pubblicazione
	
				2020
			
	Rivista in ANCE
	
				NATURE
			
	DOI
	
				https://dx.doi.org/10.1038/s41586-020-2715-9
			
	Tipologia
	
				Article (author)
			
	Appare nelle tipologie:
	
				01 - Articolo su periodico

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