It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.
Adipokines, myokines, and cardiokines: The role of nutritional interventions / P. Senesi, L. Luzi, I. Terruzzi. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 21:21(2020 Nov 08), pp. 8372.1-8372.27.
|Titolo:||Adipokines, myokines, and cardiokines: The role of nutritional interventions|
SENESI, PAMELA (Primo)
LUZI, LIVIO (Penultimo)
TERRUZZI, ILEANA MARINA (Ultimo) (Corresponding)
|Parole Chiave:||Adipokines; Cardiokines; Cardiovascular diseases; Metabolic syndrome; Myokines; Nutraceuticals; Obesity|
|Settore Scientifico Disciplinare:||Settore MED/49 - Scienze Tecniche Dietetiche Applicate|
|Data di pubblicazione:||8-nov-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/ijms21218372|
|Appare nelle tipologie:||01 - Articolo su periodico|