Introduction: In Italy, the real-world evidence on the extent of adherence to guidelines and the benefits of recommended therapeutic medications and their impact on the quality of life (QoL) of H1-antihistamines (H1-AH) refractory chronic urticaria (CU) patients is limited. Methods: AWARE (A World-wide Antihistamine-Refractory chronic urticaria patient Evaluation) was a global prospective, non-interventional study of CU in real-world setting which included patients aged ≥18 years with a medically confirmed diagnosed of CU present for more than 2 months. In this study, the disease characteristics, pharmacological treatments and patient-reported outcomes (PROs) are reported. Results: In total, 159 patients from 24 study centres in Italy completed the study. At baseline, 221 (89.5%) and 8 (3.2%) patients had chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), respectively, while 18 (7.3%) patients had concomitant CSU and CIndU. For CSU patients, mean dermatology life quality index and CU quality of life questionnaire scores reduced to 3.0 ± 4.9 and 14.6 ± 18.6 at Month 24 from baseline scores of 7.5 ± 6.6 and 33.2 ± 19.5, respectively, indicating an improvement in QoL. This was reflected in their work-life as work productivity impairment reduced considerably after 2 years. Only 71.9% CSU patients had a prior treatment, while during the study, 96.8% of the patients were treated with a medication. At baseline, only 52.9% CSU patients reported nonsedating H1-antihistamines as first-line of treatment in prior medication, this increased to 89.6% during current medication. Conclusion: This study shows that CSU has a considerable socio-economic burden and an improvement in QoL can be achieved in CSU patients if an appropriate therapeutic path is followed.
Socio-economic burden and resource utilisation in Italian patients with chronic urticaria : 2-year data from the AWARE study / O. Rossi, A. Piccirillo, E. Iemoli, A. Patrizi, L. Stingeni, S. Calvieri, M. Gola, P. Dapavo, A. Cristaudo, L. Zichichi, L. Losappio, F. Saccheri, E.A. Pastorello. - In: THE WORLD ALLERGY ORGANIZATION JOURNAL. - ISSN 1939-4551. - 13:12(2020 Dec), pp. 100470.1-100470.12.
|Titolo:||Socio-economic burden and resource utilisation in Italian patients with chronic urticaria : 2-year data from the AWARE study|
|Parole Chiave:||AWARE study; Italy; chronic spontaneous urticaria; socio-economic burden; resource utilisation|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||dic-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.waojou.2020.100470|
|Appare nelle tipologie:||01 - Articolo su periodico|