Human herpesvirus 6 (HHV-6) can integrate its genome in human chromosomes and be germline transmitted (inherited chromosomally integrated HHV-6). We report a case of chromosomally integrated HHV-6 inherited from the mother unexpectedly diagnosed in a septic neonate. Since HHV-6 has recently been included in multiplex polymerase chain reaction assays for meningitis/encephalitis, diagnosing inherited chromosomally integrated HHV-6 status is essential to avoid misdiagnosis of active HHV-6 infection and unnecessary antiviral treatment.
Inherited Chromosomally Integrated Human Herpesvirus 6 : An Unexpected Finding in a Septic Neonate / L. Pugni, C. Pietrasanta, A. Ronchi, G. Lunghi, L. Pellegrinelli, F. Mosca, G. Campanini, F. Baldanti. - In: THE PEDIATRIC INFECTIOUS DISEASE JOURNAL. - ISSN 0891-3668. - 40:1(2021 Jan), pp. 74-75. [10.1097/INF.0000000000002905]
Inherited Chromosomally Integrated Human Herpesvirus 6 : An Unexpected Finding in a Septic Neonate
L. Pugni
;C. Pietrasanta;A. Ronchi;L. Pellegrinelli;F. Mosca;G. Campanini;
2021
Abstract
Human herpesvirus 6 (HHV-6) can integrate its genome in human chromosomes and be germline transmitted (inherited chromosomally integrated HHV-6). We report a case of chromosomally integrated HHV-6 inherited from the mother unexpectedly diagnosed in a septic neonate. Since HHV-6 has recently been included in multiplex polymerase chain reaction assays for meningitis/encephalitis, diagnosing inherited chromosomally integrated HHV-6 status is essential to avoid misdiagnosis of active HHV-6 infection and unnecessary antiviral treatment.
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