Neurodegenerative disorders are a family of incurable conditions. Among them, Alzheimer's disease and tauopathies are the most common. Pathological features of these two disorders are synaptic loss, neuronal cell death and increased DNA damage. A key pathological protein for the onset and progression of the conditions is the protein tau, a microtubule-binding protein highly expressed in neurons and encoded by the MAPT (microtubule-associated protein tau) gene. Tau is predominantly a cytosolic protein that interacts with numerous other proteins and molecules. Recent findings, however, have highlighted new and unexpected roles for tau in the nucleus of neuronal cells. This review summarizes the functions of tau in the metabolism of DNA, describing them in the context of the disorders.
Tau and DNA Damage in Neurodegeneration / L. Colnaghi, D. Rondelli, M. Muzi-Falconi, S. Sertic. - In: BRAIN SCIENCES. - ISSN 2076-3425. - 10:12(2020 Dec 07).
Titolo: | Tau and DNA Damage in Neurodegeneration |
Autori: | COLNAGHI, LUCA (Primo) RONDELLI, DIEGO (Secondo) MUZI FALCONI, MARCO (Penultimo) SERTIC, SARAH (Ultimo) (Corresponding) |
Parole Chiave: | Alzheimer’s disease; DNA damage; tau; |
Settore Scientifico Disciplinare: | Settore BIO/11 - Biologia Molecolare |
Progetto: | PIANO DI SOSTEGNO ALLA RICERCA 2015-2017 - LINEA 2 "DOTAZIONE ANNUALE PER ATTIVITA' ISTITUZIONALE" G quadruplexes as modulators of genome stability |
Data di pubblicazione: | 7-dic-2020 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/brainsci10120946 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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