Knowledge of preoperative right heart function of adult patients with cystic fibrosis (CF) awaiting lung transplant (LUTX) is limited. The echocardiography of adult patients with CF enlisted for LUTX was retrospectively analyzed and compared with standards and invasive analyses (right heart catheterization, multigated radionuclide ventriculography). We included 49 patients (reported as mean ± standard deviation; 29 ± 9 years of age; forced expiratory volume in first second of expiration, 31% ± 11% predicted; lung allocation score, 36 ± 5; invasive mean pulmonary artery pressure, 17 ± 5 mm Hg; multigated radionuclide ventriculography right ventricle [RV] ejection fraction, 50% ± 9%). Patients had increased RV end-diastolic area, RV wall thickness, and increased pulmonary artery acceleration time with subnormal tricuspid annular plane systolic excursion, tissue Doppler positive peak systolic velocity, and fraction area change. Subnormal tricuspid annular plane systolic excursion (< 23 mm), tissue Doppler positive peak systolic velocity (< 14 cm/s), and fraction area change (< 49%) had high sensitivity and negative predictive value in predicting impaired RV. ejection fraction: A good correlation between echocardiographic estimated and invasively measured systolic pulmonary artery pressure was observed (R2 = 0.554, P < .001). Adults with CF awaiting LUTX have morphologic alterations of the right heart, with subclinical impairment of RV systolic function. Echocardiography may be used as a bedside, repeatable, and reliable noninvasive test to screen further deterioration in RV function while on the waiting list for LUTX. More prospective follow-up echocardiographic studies are necessary to confirm such a hypothesis.
Right Ventricle Dysfunction in Patients With Adult Cystic Fibrosis Enlisted for Lung Transplant / V. Scaravilli, S. Scansani, A. Grasso, A. Guzzardella, M. Vicenzi, I. Rota, M. Nosotti, A. Zanella, F.B.A. Blasi, A. Pesenti, G. Grasselli. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 53:1(2021), pp. 260-264.
|Titolo:||Right Ventricle Dysfunction in Patients With Adult Cystic Fibrosis Enlisted for Lung Transplant|
PESENTI, ANTONIO (Penultimo)
GRASSELLI, GIACOMO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/10 - Malattie dell'Apparato Respiratorio|
Settore MED/41 - Anestesiologia
Settore MED/21 - Chirurgia Toracica
|Data di pubblicazione:||2021|
|Data ahead of print / Data di stampa:||27-nov-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.transproceed.2020.09.020|
|Appare nelle tipologie:||01 - Articolo su periodico|
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