Emotional and cognitive information processing represent higher-order brain functions. They require coordinated interaction of specialized brain areas via a complex spatial and temporal equilibrium among neuronal cell-autonomous, circuitry, and network mechanisms. The delicate balance can be corrupted by stressful experiences, increasing the risk of developing psychopathologies in vulnerable individuals. Neuropsychiatric disorders affect twenty percent of the western world population, but therapies are still not effective for some patients. Elusive knowledge of molecular pathomechanisms and scarcity of objective biomarkers in humans present complex challenges, while the adoption of rodent models helps to improve our understanding of disease correlate and aids the search for novel pharmacological targets. Stress administration represents a strategy to induce, trace, and modify molecular and behavioral endophenotypes of mood disorders in animals. However, a mouse or rat model will only display one or a few endophenotypes of a specific human psychopathology, which cannot be in any case recapitulated as a whole. To override this issue, shared criteria have been adopted to deconstruct neuropsychiatric disorders, i.e., depression, into specific behavioral aspects, and inherent neurobiological substrates, also recognizable in lower mammals. In this work, we provide a rationale for rodent models of stress administration. In particular, comparing each rodent model with a real-life human traumatic experience, we intend to suggest an introductive guide to better comprehend and interpret these paradigms.
Rationale, relevance, and limits of stress-induced psychopathology in rodents as models for psychiatry research : an introductory overview / M. Italia, C. Forastieri, A. Longaretti, E. Battaglioli, F. Rusconi. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 21:20(2020 Nov 02), pp. 7455.1-7455.21.
|Titolo:||Rationale, relevance, and limits of stress-induced psychopathology in rodents as models for psychiatry research : an introductory overview|
ITALIA, MARIA (Primo) [Investigation]
FORASTIERI, CHIARA (Secondo) [Investigation]
LONGARETTI, ALESSANDRA [Investigation]
BATTAGLIOLI, ELENA [Conceptualization] (Corresponding)
RUSCONI, FRANCESCO SEBASTIANO [Conceptualization] (Corresponding)
|Parole Chiave:||Animal models; Construct validity; Face validity; Neuropsychiatric disorders; Predictive validity; Stress; Stress-induced psychopathology|
|Settore Scientifico Disciplinare:||Settore BIO/13 - Biologia Applicata|
|Progetto:||PIANO DI SOSTEGNO ALLA RICERCA 2015-2017 - LINEA 2 "DOTAZIONE ANNUALE PER ATTIVITA' ISTITUZIONALE"|
Role of LSD1 in aging-dependent epigenetic drift leading to frailty-associated mood disorders
|Data di pubblicazione:||9-ott-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/ijms21207455|
|Appare nelle tipologie:||01 - Articolo su periodico|