Antitussive activity of the new antitussive drug, levodropropizine (S(-)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol, DF 526), was evaluated in healthy volunteers by the classical method of citric acid-induced coughing. Levodropropizine dose-dependently reduced cough frequency. Maximal inhibition was observed at 6 h after administration. Cough intensity was also reduced, as shown by the analysis of cough noise. Levodropropizine, at the dosage of 60 mg t.i.d., had no adverse effects on respiratory function nor on airway clearance mechanisms: in fact, id did not affect spirometric parameters. Levodropropizine had no effects on the rheological properties of mucus nor on ciliary activity of airway epithelium.
Antitussive activity and respiratory system effects of levodropropizine in man / R. Bossi, P.C. Braga, S. Centanni, D. Legnani, N.E. Moavero, L. Allegra. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - 38:8(1988), pp. 1159-1162.
|Titolo:||Antitussive activity and respiratory system effects of levodropropizine in man|
|Settore Scientifico Disciplinare:||Settore MED/10 - Malattie dell'Apparato Respiratorio|
|Data di pubblicazione:||1988|
|Appare nelle tipologie:||01 - Articolo su periodico|