Wound Healing in Pyoderma Gangrenosum

Pyoderma gangrenosum (PG) is an ulcerative painful, chronic neutrophilic dermatosis that is often associated with an underlying illness. There is limited evidence on the best treatment for PG, and first-line systemic therapies are associated with adverse events. In order to optimize therapeutics, topical therapy and local wound care should be carefully addressed. Topical therapies for PG include topical and intralesional immunosuppressants, immunomodulators, and alternative therapies. Multiple moisture-retentive dressings and compression therapy have been used to promote healing. Less often used but still beneficial for more severe cases are negative pressure wound therapy and skin substitutes. PG is not only a physical disease but affects patients psychologically as well. A therapeutic relationship must be maintained to provide holistic care and achieve common ground with the patient in order to ensure patient adherence.