Mitochondria represent the energy hub of cells and their function is under the constant influence of their tethering with other subcellular organelles. Mitochondria interact with the endoplasmic reticulum, lysosomes, cytoskeleton, peroxisomes, and nucleus in several ways, ranging from signal transduction, vesicle transport, and membrane contact sites, to regulate energy metabolism, biosynthetic processes, apoptosis, and cell turnover. Tumorigenesis is often associated with mitochondrial dysfunction, which could likely be the result of an altered interaction with different cell organelles or structures. The purpose of the present review is to provide an updated overview of the links between inter-organellar communications and interactions and metabolism in cancer cells, with a focus on mitochondria. The very recent publication of several reviews on these aspects testifies the great interest in the area. Here, we aim at (1) summarizing recent evidence supporting that the metabolic rewiring and adaptation observed in tumors deeply affect organelle dynamics and cellular functions and vice versa; (2) discussing insights on the underlying mechanisms, when available; and (3) critically presenting the gaps in the field that need to be filled, for a comprehensive understanding of tumor cells’ biology. Chemo-resistance and druggable vulnerabilities of cancer cells related to the aspects mentioned above is also outlined.
The Loss of Golden Touch: Mitochondria-Organelle Interactions, Metabolism, and Cancer / M. Audano, S. Pedretti, S. Ligorio, M. Crestani, D. Caruso, E.S.R. De Fabiani, N. Mitro. - In: CELLS. - ISSN 2073-4409. - 9:11(2020 Nov 11).
|Titolo:||The Loss of Golden Touch: Mitochondria-Organelle Interactions, Metabolism, and Cancer|
AUDANO, MATTEO (Primo)
PEDRETTI, SILVIA (Secondo)
DE FABIANI, EMMA SELINA ROSA (Penultimo) (Corresponding)
MITRO, NICO (Ultimo) (Corresponding)
|Parole Chiave:||mitochondria; cancer; metabolism; subcellular organelles:|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||11-nov-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/cells9112519|
|Appare nelle tipologie:||01 - Articolo su periodico|