The design and synthesis of multifunctional nanomaterials could lead to applications relevant for biomedicine. Manufacturing porous particles to make them able to carry bioactive molecules into living cells represents a substantial goal towards the development of powerful tools for nanomedicine. This work describes a first example of using zeolite-L crystals as multifunctional nanocontainers to simultaneously deliver DNA oligonucleotides and organic molecules into living cells. Multifunctional zeolite-L was prepared by filling the pore system with guest molecules, whilst DNA was adsorbed electrostatically on their surface. The release kinetics of DNA and of the guest molecules into living cells was studied to prove the multiple-drug-delivery ability of the system. The localization of all the components in different cellular compartments was followed. The presented system may be a prototype for the development of novel nanoparticles for drug delivery and gene therapy.

Multifunctional inorganic nanocontainers for DNA and drug delivery into living cells / H. Lulf, A. Bertucci, D. Septiadi, R. Corradini, L. De Cola. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 20:35(2014), pp. 10900-10904. [10.1002/chem.201403232]

Multifunctional inorganic nanocontainers for DNA and drug delivery into living cells

L. De Cola
2014

Abstract

The design and synthesis of multifunctional nanomaterials could lead to applications relevant for biomedicine. Manufacturing porous particles to make them able to carry bioactive molecules into living cells represents a substantial goal towards the development of powerful tools for nanomedicine. This work describes a first example of using zeolite-L crystals as multifunctional nanocontainers to simultaneously deliver DNA oligonucleotides and organic molecules into living cells. Multifunctional zeolite-L was prepared by filling the pore system with guest molecules, whilst DNA was adsorbed electrostatically on their surface. The release kinetics of DNA and of the guest molecules into living cells was studied to prove the multiple-drug-delivery ability of the system. The localization of all the components in different cellular compartments was followed. The presented system may be a prototype for the development of novel nanoparticles for drug delivery and gene therapy.
DNA; drug delivery; fluorescence; mesoporous materials; nanotechnology; zeolites
Settore CHIM/03 - Chimica Generale e Inorganica
2014
Article (author)
File in questo prodotto:
File Dimensione Formato  
chem.201403232.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 2.08 MB
Formato Adobe PDF
2.08 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/791400
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 39
  • ???jsp.display-item.citation.isi??? 39
social impact