Magnesium is an essential element of life, involved in the regulation of metabolism and homeostasis of all the tissues. It also regulates immunological functions, acting on the cells of innate and adaptive immune systems. Magnesium deficiency primes phagocytes, enhances granulocyte oxidative burst, activates endothelial cells and increases the levels of cytokines, thus promoting inflammation. Consequently, a low magnesium status, which is often underdiagnosed, potentiates the reactivity to various immune challenges and is implicated in the pathophysiology of many common chronic diseases. Here we summarize recent advances supporting the link between magnesium deficiency, inflammatory responses and diseases, and offer new hints towards a better understanding of the underlying mechanisms.

Magnesium and inflammation : Advances and perspectives / J.A. Maier, S. Castiglioni, L. Locatelli, M. Zocchi, A. Mazur. - In: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. - ISSN 1084-9521. - (2020 Nov 18). [Epub ahead of print] [10.1016/j.semcdb.2020.11.002]

Magnesium and inflammation : Advances and perspectives

J.A. Maier
Primo
;
S. Castiglioni
Secondo
;
L. Locatelli;M. Zocchi;
2020-11-18

Abstract

Magnesium is an essential element of life, involved in the regulation of metabolism and homeostasis of all the tissues. It also regulates immunological functions, acting on the cells of innate and adaptive immune systems. Magnesium deficiency primes phagocytes, enhances granulocyte oxidative burst, activates endothelial cells and increases the levels of cytokines, thus promoting inflammation. Consequently, a low magnesium status, which is often underdiagnosed, potentiates the reactivity to various immune challenges and is implicated in the pathophysiology of many common chronic diseases. Here we summarize recent advances supporting the link between magnesium deficiency, inflammatory responses and diseases, and offer new hints towards a better understanding of the underlying mechanisms.
magnesium; inflammation; COVID-19; non-communicable diseases; TRPM7; MagT1
Settore MED/04 - Patologia Generale
18-nov-2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/790371
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