CSNK2A2 gene, 16q21, has a role in regulating the phosphorylation and circulation of old proteasomes by encoding the catalytic α' subunit of casein kinase 2 (CK2α'). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins. It can regulate Wnt signalling by phosphorylating CTNNB1 and the transcription factor LEF1 and for this reason, it is involved in some cellular key processes such as cell cycle progression, inhibition of apoptosis, DNA damage repair, differentiation and transcription but also viral infection. CSNK2A2 is a cancer-related gene and its upregulation has been detected is many cancers such as glioblastoma multiforme, colorectal cancer, breast cancer and ovarian cancer, and also in some diseases such as diabetes, theileriasis in cattle and distal muscular dystrophy with anterior tibial onset in mice are associated with CSNK2A2.

CSNK2A2 (casein kinase 2 alpha 2) / N. Abazari, A. Beghini. - In: ATLAS OF GENETICS AND CYTOGENETICS IN ONCOLOGY AND HAEMATOLOGY. - ISSN 1768-3262. - (2020 Nov 01), pp. 40171.1-40171.11.

CSNK2A2 (casein kinase 2 alpha 2)

N. Abazari;A. Beghini
Ultimo
2020

Abstract

CSNK2A2 gene, 16q21, has a role in regulating the phosphorylation and circulation of old proteasomes by encoding the catalytic α' subunit of casein kinase 2 (CK2α'). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins. It can regulate Wnt signalling by phosphorylating CTNNB1 and the transcription factor LEF1 and for this reason, it is involved in some cellular key processes such as cell cycle progression, inhibition of apoptosis, DNA damage repair, differentiation and transcription but also viral infection. CSNK2A2 is a cancer-related gene and its upregulation has been detected is many cancers such as glioblastoma multiforme, colorectal cancer, breast cancer and ovarian cancer, and also in some diseases such as diabetes, theileriasis in cattle and distal muscular dystrophy with anterior tibial onset in mice are associated with CSNK2A2.
Kinase; Serine/threonine-protein kinase; CSNK2A2; CK2A2; CSNK2A1; CK2alpha
Settore BIO/11 - Biologia Molecolare
Settore BIOS-08/A - Biologia molecolare
1-nov-2020
http://atlasgeneticsoncology.org/gene/40171/csnk2a2-(casein-kinase-2-alpha-2)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/790124
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