miR-205 plays important roles in the physiology of epithelia by regulating a variety of pathways that govern differentiation and morphogenesis. Its aberrant expression is frequently found in human cancers, where it was reported to act either as tumor-suppressor or oncogene depending on the specific tumor context and target genes. miR-205 expression and function in different cell types or processes are the result of the complex balance among transcription, processing and stability of the microRNA. In this review, we summarize the principal mechanisms that regulate miR-205 expression at the transcriptional and post-transcriptional level, with particular focus on the transcriptional relationship with its host gene. Elucidating the mechanisms and factors regulating miR-205 expression in different biological contexts represents a fundamental step for a better understanding of the contribution of such pivotal microRNA to epithelial cell function in physiology and disease, and for the development of modulation strategies for future application in cancer therapy.

Unveiling the ups and downs of miR-205 in physiology and cancer: transcriptional and post-transcriptional mechanisms / E. Ferrari, P. Gandellini. - In: CELL DEATH & DISEASE. - ISSN 2041-4889. - 11:11(2020 Nov 15). [10.1038/s41419-020-03192-4]

Unveiling the ups and downs of miR-205 in physiology and cancer: transcriptional and post-transcriptional mechanisms

P. Gandellini
Ultimo
2020

Abstract

miR-205 plays important roles in the physiology of epithelia by regulating a variety of pathways that govern differentiation and morphogenesis. Its aberrant expression is frequently found in human cancers, where it was reported to act either as tumor-suppressor or oncogene depending on the specific tumor context and target genes. miR-205 expression and function in different cell types or processes are the result of the complex balance among transcription, processing and stability of the microRNA. In this review, we summarize the principal mechanisms that regulate miR-205 expression at the transcriptional and post-transcriptional level, with particular focus on the transcriptional relationship with its host gene. Elucidating the mechanisms and factors regulating miR-205 expression in different biological contexts represents a fundamental step for a better understanding of the contribution of such pivotal microRNA to epithelial cell function in physiology and disease, and for the development of modulation strategies for future application in cancer therapy.
Settore MED/04 - Patologia Generale
   Dissecting the role of unexplored miR-205 host gene al long non-coding RNA in prostate basal cells: implications for cancer development
   FONDAZIONE CARIPLO
   2015-0866
15-nov-2020
Article (author)
File in questo prodotto:
File Dimensione Formato  
s41419-020-03192-4.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 762.06 kB
Formato Adobe PDF
762.06 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/789750
Citazioni
  • ???jsp.display-item.citation.pmc??? 25
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 33
social impact