The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism. In this perspective article, we focus on microscopic evidences of the pivotal role of MERCs/MAMs and their changes in metabolic diseases, like obesity, diabetes, and neurodegeneration.
Perspective : Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy / A. Stacchiotti, G. Favero, A. Lavazza, R. Garcia-Gomez, M. Monsalve, R. Rezzani. - In: CELLS. - ISSN 2073-4409. - 8:1(2019), pp. 5.1-5.9. [10.3390/cells8010005]
Perspective : Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy
A. Stacchiotti
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2019
Abstract
The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism. In this perspective article, we focus on microscopic evidences of the pivotal role of MERCs/MAMs and their changes in metabolic diseases, like obesity, diabetes, and neurodegeneration.File | Dimensione | Formato | |
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