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IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishThe improvement of the pharmacological profile of lipophilic drug formulations is one of the main successes achieved using nanoparticles (NPs) in medicine. However, the complex synthesis procedure and numerous post-processing steps hamper the cost-effective use of these formulations. In this work, an approach which requires only a syringe to produce self-assembling biodegradable and biocompatible poly(caprolactone)-based NPs is developed. The effective synthesis of monodisperse NPs has been made possible by the optimization of the block-copolymer synthesized via a combination of ring opening polymerization and reversible addition-fragmentation chain transfer polymerization. These NPs can be used to formulate lipophilic drugs that are barely soluble in water, such as trabectedin, a potent anticancer therapeutic. Its biodistribution and antitumor activity have been compared with the commercially available formulation Yondelis®. The results indicate that this trabectedin NP formulation performs with the same antitumor activity as Yondelis®, but does not have the drawback of severe local vascular toxicity in the injection site.
Readily prepared biodegradable nanoparticles to formulate poorly water soluble drugs improving their pharmacological properties : the example of trabectedin / U. Capasso Palmiero, L. Morosi, E. Bello, M. Ponzo, R. Frapolli, C. Matteo, M. Ferrari, M. Zucchetti, L. Minoli, M. De Maglie, P. Romanelli, M. Morbidelli, M. D'Incalci, D. Moscatelli. - In: JOURNAL OF CONTROLLED RELEASE. - ISSN 0168-3659. - 276(2018), pp. 140-149.
| Titolo: | Readily prepared biodegradable nanoparticles to formulate poorly water soluble drugs improving their pharmacological properties : the example of trabectedin |
| Autori: | |
| Parole Chiave: | Biodegradable; Nanoparticles; Phlebitis; Polycaprolactone; Polyethylen glycol; Trabectedin; Vascular toxicity; Animals; Female; Liposarcoma; Mice, Inbred C57BL; Mice, Nude; Polymers; Skin; Solubility; Tissue Distribution; Water; Antineoplastic Agents, Alkylating; Nanoparticles; Trabectedin |
| Settore Scientifico Disciplinare: | Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria |
| Data di pubblicazione: | 2018 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jconrel.2018.03.005 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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