Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics : results from the EPIC cohort

Ose, J.; Fortner, R.T.; Schock, H.; Peeters, P.H.; Onland-Moret, N.C.; Bueno-De-Mesquita, H.B.; Weiderpass, E.; Gram, I.T.; Overvad, K.; Tjonneland, A.; Dossus, L.; Fournier, A.; Baglietto, L.; Trichopoulou, A.; Benetou, V.; Trichopoulos, D.; Boeing, H.; Masala, G.; Krogh, V.; Matiello, A.; Tumino, R.; Popovic, M.; Obon-Santacana, M.; Larranaga, N.; Ardanaz, E.; Sanchez, M.-.; Menendez, V.; Chirlaque, M.-.; Travis, R.C.; Khaw, K.-.; Brandstedt, J.; Idahl, A.; Lundin, E.; Rinaldi, S.; Kuhn, E.; Romieu, I.; Gunter, M.J.; Merritt, M.A.; Riboli, E.; Kaaks, R.

doi:10.1038/bjc.2014.566

Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics : results from the EPIC cohort / J. Ose, R.T. Fortner, H. Schock, P.H. Peeters, N.C. Onland-Moret, H.B. Bueno-De-Mesquita, E. Weiderpass, I.T. Gram, K. Overvad, A. Tjonneland, L. Dossus, A. Fournier, L. Baglietto, A. Trichopoulou, V. Benetou, D. Trichopoulos, H. Boeing, G. Masala, V. Krogh, A. Matiello, R. Tumino, M. Popovic, M. Obon-Santacana, N. Larranaga, E. Ardanaz, M.-. Sanchez, V. Menendez, M.-. Chirlaque, R.C. Travis, K.-. Khaw, J. Brandstedt, A. Idahl, E. Lundin, S. Rinaldi, E. Kuhn, I. Romieu, M.J. Gunter, M.A. Merritt, E. Riboli, R. Kaaks. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - 112:1(2015), pp. 162-166. [10.1038/bjc.2014.566]